Histopathological variant types diagnosed in prostate surgery

Rare pathological variants may only be diagnosed after the surgical treatments applied. We aimed to determine the rare variant pathologies and their frequencies diagnosed in prostate surgeries performed in routine patient care. We retrospectively analyzed hospital pathology records for all prostate surgeries performed namely TUR-P, open prostatectomy, and radical prostatectomy between October 2014 and October 2019. A total of 1345 patients’ clinical data together with relevant prostate surgery pathologic diagnoses were evaluated from the database. Their mean age was 67.63±8.09. The most common comorbid diseases were hypertension (46%), diabetes mellitus (21%) and cerebrovascular disease (23%). Surgeries indicated and performed for prostate diseases were TUR-P (72%), open prostatectomy (9.7%) and radical prostatectomy (18.4%). The respective median PSA values for above mentioned surgery groups were 3.21, 7.34 and 8.13 ng/ml. Ninety-three patients (6.9%) had variant pathology associated with their primary pathologies including either BPH or prostate adenocarcinoma. 8.6% of patients with variant pathology had more than one variant types. Histopathological variant types generally considered rare can be seen up to 20% in oncological cases according to our database and their clinical importance and treatment differs for each variant type.