Ocrelizumab治疗并发多发性硬化症患者慢性炎性脱髓鞘性多神经病变的恢复

IF 2.6 Q2 CLINICAL NEUROLOGY Journal of Central Nervous System Disease Pub Date : 2022-01-01 DOI:10.1177/11795735221084837

M. Auer, H. Hegen, A. Hotter, W. Löscher, K. Berek, Anne Zinganell, E. Fava, Paul Rhomberg, F. Deisenhammer, F. Di Pauli

{"title":"Ocrelizumab治疗并发多发性硬化症患者慢性炎性脱髓鞘性多神经病变的恢复","authors":"M. Auer, H. Hegen, A. Hotter, W. Löscher, K. Berek, Anne Zinganell, E. Fava, Paul Rhomberg, F. Deisenhammer, F. Di Pauli","doi":"10.1177/11795735221084837","DOIUrl":null,"url":null,"abstract":"The chimeric anti-CD20 antibody rituximab has demonstrated good efficacy as an off-label treatment in chronic inflammatory demyelinating polyneuropathy (CIDP), while the humanized anti-CD20 antibody ocrelizumab has been approved for treatment of multiple sclerosis (MS), whereas there is no evidence for its use in CIDP so far. We present a patient suffering from CIDP and MS, both refractory to standard treatment and both showing marked improvement on ocrelizumab. To the best of our knowledge, this is a unique report of CIDP with an almost full electrophysiological recovery on ocrelizumab which could be considered as a potential treatment option for refractory CIDP.","PeriodicalId":15218,"journal":{"name":"Journal of Central Nervous System Disease","volume":" ","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Recovery of Chronic Inflammatory Demyelinating Polyneuropathy on Treatment With Ocrelizumab in a Patient With Co-Existing Multiple Sclerosis\",\"authors\":\"M. Auer, H. Hegen, A. Hotter, W. Löscher, K. Berek, Anne Zinganell, E. Fava, Paul Rhomberg, F. Deisenhammer, F. Di Pauli\",\"doi\":\"10.1177/11795735221084837\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The chimeric anti-CD20 antibody rituximab has demonstrated good efficacy as an off-label treatment in chronic inflammatory demyelinating polyneuropathy (CIDP), while the humanized anti-CD20 antibody ocrelizumab has been approved for treatment of multiple sclerosis (MS), whereas there is no evidence for its use in CIDP so far. We present a patient suffering from CIDP and MS, both refractory to standard treatment and both showing marked improvement on ocrelizumab. To the best of our knowledge, this is a unique report of CIDP with an almost full electrophysiological recovery on ocrelizumab which could be considered as a potential treatment option for refractory CIDP.\",\"PeriodicalId\":15218,\"journal\":{\"name\":\"Journal of Central Nervous System Disease\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Central Nervous System Disease\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/11795735221084837\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Central Nervous System Disease","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/11795735221084837","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

摘要

嵌合抗CD20抗体利妥昔单抗已被证明是慢性炎症性脱髓鞘性多发性神经病（CIDP）的标签外治疗的良好疗效，而人源化抗CD20单克隆抗体ocrelizumab已被批准用于治疗多发性硬化症（MS），而迄今为止还没有证据表明其在CIDP中使用。我们报告了一名患有CIDP和MS的患者，这两种疾病都对标准治疗难以治疗，并且都在ocrelizumab上表现出显著的改善。据我们所知，这是一份独特的CIDP报告，ocrelizumab的电生理恢复几乎完全，可被视为难治性CIDP的潜在治疗选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Recovery of Chronic Inflammatory Demyelinating Polyneuropathy on Treatment With Ocrelizumab in a Patient With Co-Existing Multiple Sclerosis

The chimeric anti-CD20 antibody rituximab has demonstrated good efficacy as an off-label treatment in chronic inflammatory demyelinating polyneuropathy (CIDP), while the humanized anti-CD20 antibody ocrelizumab has been approved for treatment of multiple sclerosis (MS), whereas there is no evidence for its use in CIDP so far. We present a patient suffering from CIDP and MS, both refractory to standard treatment and both showing marked improvement on ocrelizumab. To the best of our knowledge, this is a unique report of CIDP with an almost full electrophysiological recovery on ocrelizumab which could be considered as a potential treatment option for refractory CIDP.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊