Major Depression Induced Endocrine Modulation is a Risk Factor for Low bone Mineral Density in Premenopausal Women

Background: The significant physiological effects of psychological depression are beginning to berecognized as exacerbating common diseases, including osteoporosis. This review discusses the currentevidence for psychological depression-associated mental health disorders as risk factors for osteoporosis,the mechanisms that may link these conditions, and potential implications for treatmentOsteoporosis is a major public health threat and depression is second most important cause of disabilityworldwide in 2020. Several studies have reported an association between depression and low bone mineraldensity, but a causal link between these two conditions is disputed.We propose that depression induces earlybone loss in premenopausal women, primarily via specific endocrine mechanisms associated poor lifestylehabits contributory.Aim and Objectives: To find the clinical correlation between depression, serum cortisol, vitamin D,hypothyroidism and BMD in Premenopausal Women.To find out a new risk factor of secondary osteoporosis in premenopausal women.Methods: The study group consisted of 80 osteoporotic female patient’s age range between 30-60years.Thestate of depression was analyzed by using Ham D scale. BMD and endocrine parameters was measured byDEXA and chemiluminisence,ELISA. Statistical correlation analyzed by SPSS22software.Results: A highly significant (P <0.00001) correlation was observedbetween HAM-D score and serumcortisol. The correlation between HAM-D and BMD was also significant (P <0.05).No significant correlationwas found between BMD and serum cortisol (P? 0.05).The correlation of serum vitamin D with BMD wasfar more significant (P<0.00001) compared to the association with TSH (P<0.0001).Discussion & Conclusion: A high score of depression associated with low vitamin D level or high serumcortisol and TSH level which is a risk factor for low BMD in premenopausal women to develop secondaryosteoporosisIt can be concluded that Irrespective of the specific causes, subjects with depression should be consideredfor screening for bone mineral density and, vice versa, subjects with low BMD should be considered forscreening for depression in early stage of life and supplementation of vitamin D with regular physicalactivity in premenopausal women for prevention of secondary osteoporosis.