严重急性营养不良的肠道失调不是不成熟:不可逆转的定量-定性范式转变

Q1 Medicine Human Microbiome Journal Pub Date : 2020-03-01 DOI:10.1016/j.humic.2019.100067

Matthieu Million , Didier Raoult

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引用次数: 2

摘要

我们饶有兴趣地阅读了戈登团队的一项工作，报告了严重急性营养不良的肠道微生物群不成熟。然而，几乎所有的肠道微生物都存在于初乳和母乳中，包括产甲烷的古生菌。这些古生菌可在婴儿的胃中检测到，在40%的健康对照儿童中检测到，但在严重急性营养不良中会丢失。短双歧杆菌和长双歧杆菌是不成熟的其他例外。这些错误是至关重要的，因为它们是治疗和治愈这些儿童的关键。我们认为，包括双歧杆菌、乳酸杆菌和古菌在内的牛奶益生菌可能是营养不良管理的下一次革命。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Gut dysbiosis in severe acute malnutrition is not an immaturity: The irreversible quantitative-qualitative paradigm shift

We read with interest a work of the Gordon team reporting a gut microbiota immaturity in severe acute malnutrition. However, almost all gut microbes are found in colostrum and breast milk, including methanogenic Archaea. These Archaea are detected in baby’s stomach and in 40% healthy control children but are lost in severe acute malnutrition. Bifidobacterium breve and Bifidobacterium longum are other exceptions to immaturity. These errors are critical because they are a key to treat and cure these children. We argue that milk probiotics including Bifidobacterium, Lactobacillus and Archaea could be the next revolution in the management of malnutrition.

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Human Microbiome Journal Medicine-Infectious Diseases

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期刊介绍： The innumerable microbes living in and on our bodies are known to affect human wellbeing, but our knowledge of their role is still at the very early stages of understanding. Human Microbiome is a new open access journal dedicated to research on the impact of the microbiome on human health and disease. The journal will publish original research, reviews, comments, human microbe descriptions and genome, and letters. Topics covered will include: the repertoire of human-associated microbes, therapeutic intervention, pathophysiology, experimental models, physiological, geographical, and pathological changes, and technical reports; genomic, metabolomic, transcriptomic, and culturomic approaches are welcome.

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