慢性炎症过程中脂质交换、血小板阻滞止血、全身反应性等指标相互作用及其对人体心身协调影响的研究

IF 0.4 Q4 CHEMISTRY, ANALYTICAL French-Ukrainian Journal of Chemistry Pub Date : 2019-12-24 DOI:10.17721/fujcv7i2p120-137
I. Sokolovskaya, A. Kutsak, V. Zarytska, Valentina Nechiporenko, Natalia Gordiyenko, Yuliia Siliavina, K. Horash, Oleg Plakhotnik
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引用次数: 0

摘要

在临床和实验室研究的基础上,首次揭示了生殖系统慢性炎症过程患者血脂代谢指标、止血血小板水平与全身反应性的相关性。炎症性疾病病程的新的发病机制已经确立。研究表明,慢性炎症过程伴随着脂质代谢紊乱。这些变化的严重程度取决于炎症过程的严重程度、多形核白细胞吞噬活性的降低、巨噬细胞的激活和特定的细胞机制,并伴有自身中毒。可以确定的是,动脉粥样硬化性异常脂蛋白血症的频率以及脂质过氧化的强度随着被检查患者年龄的增加而增加。大多数致动脉粥样硬化性脂蛋白异常血症见于病毒和衣原体感染的患者。总结相关分析的数据,我们可以确定生殖系统慢性炎症过程患者血浆动脉粥样硬化特性的增长与血小板黏附聚集特性的增加和血管内皮的损伤是一致的。在中性粒细胞活性降低的背景下,这些转变与单核细胞-巨噬细胞吞噬连锁的优势以及免疫病理反应发展的细胞机制同时发生。
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Investigation of aspects of the interaction of the indicators of lipid exchange, trombocitarian block of hemostasis, total body reactivity and their influence on the psychosomatic harmonization of the man in chronic inflammatory processes
For the first time on the basis of clinical and laboratory researches were revealed the correlation of indicators of lipid metabolism, platelet level of hemostasis and general reactivity in patients with chronic inflammatory processes of the genital system. The new pathogenetic aspects of the course of inflammatory diseases have been established. It has been shown that chronic inflammatory process is accompanied by disorders of lipid metabolism. The degree of severity of these changes depends on the severity of the inflammatory process, the reduction of phagocytic activity of polymorphonuclear leukocytes and the activation of macrophage and specific cellular mechanisms, accompanied by auto-intoxication. It is established that the frequency of atherogenic dyslipoproteinemias, as well as the intensity of lipid peroxidation increases in accordance with the increase age of the examined patients. Most atherogenic dyslipoproteinemias are found in patients with viral and chlamydial infections. The summarized data of the correlation analysis allow us to establish that the growth of atherogenic properties of blood plasma of patients with chronic inflammatory processes of the reproductive system occurs in accordance with the increase of adhesive-aggregation properties of platelets and damage of the vascular endothelium. These shifts occur in parallel with the predominance of the monocyte-macrophage linkage of phagocytosis against the background of reduced activity of neutrophils and cellular mechanisms of development of immunopathological reactions.
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French-Ukrainian Journal of Chemistry
French-Ukrainian Journal of Chemistry CHEMISTRY, ANALYTICAL-
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审稿时长
4 weeks
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