吉利德科学公司奥司他韦的发现和开发

IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES Antiviral Therapy Pub Date : 2022-04-01 DOI:10.1177/13596535211067598
U. Schmitz, S. Swaminathan
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引用次数: 0

摘要

约翰·马丁于2021年3月英年早逝,这对我们个人、吉利德科学公司、他30多年来建立的公司以及关注抗病毒疗法的科学界来说都是一个巨大的损失。我们希望通过复述达菲的发现和历史以及他对达菲的贡献来纪念约翰的遗产。如果没有他的远见、毅力和对机会的敏锐眼光,达菲就不会存在,吉利德的道路也不会一样。在我们仍处于严重急性呼吸系统综合征冠状病毒2型大流行的今天,他对第一种口服流感药物的战略思考仍然非常重要。约翰在2020年5月接受科学历史研究所采访时简单地解释了这一点:“……我的大多数同事,当我们去国际旅行时,我们都会带着达菲旅行,因为它对治疗和预防有效,希望最终除了疫苗之外,新冠肺炎病毒也会有这样的解决方案。大多数人每年都会接种流感疫苗,但仍有疾病,我们需要一片治疗和预防药物。”
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Discovery and development of oseltamivir at Gilead Sciences
John Martin’s untimely death in March 2021 was a huge loss for us personally, Gilead Sciences, the company he built over 30 years and the scientific community concerned with antiviral therapies. We wish to honor John’s legacy by retelling the discovery and history of Tamiflu and his contributions to it. Without his vision, persistence, and keen eye for opportunities, Tamiflu would not exist and Gilead’s path would not have been the same. His strategic thinking around the first oral flu drug is still quite relevant today, when we are still in the SARS-CoV-2 pandemic. John explained it simply in an interview with the Science History Institute in May 2020: “…most of my colleagues, we travel with Tamiflu when we go internationally, because it works for treatment and prevention, and hopefully, there will be a solution like that, eventually, for the Covid virus in addition to vaccines. Most people will get a flu vaccine every year, but there is still disease, we need a pill for treatment and prevention.”
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来源期刊
Antiviral Therapy
Antiviral Therapy 医学-病毒学
CiteScore
2.60
自引率
8.30%
发文量
35
审稿时长
4-8 weeks
期刊介绍: Antiviral Therapy (an official publication of the International Society of Antiviral Research) is an international, peer-reviewed journal devoted to publishing articles on the clinical development and use of antiviral agents and vaccines, and the treatment of all viral diseases. Antiviral Therapy is one of the leading journals in virology and infectious diseases. The journal is comprehensive, and publishes articles concerning all clinical aspects of antiviral therapy. It features editorials, original research papers, specially commissioned review articles, letters and book reviews. The journal is aimed at physicians and specialists interested in clinical and basic research.
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