Nicolas Naïditch , Coline Hehn , Amine Ounajim , Guy Fagherazzi , Antonia Gasch-Illescas , Ben Braithwaite , Jean-François Thébaut
{"title":"PRODIAB:在糖尿病患者中使用患者报告的结果测量的观点","authors":"Nicolas Naïditch , Coline Hehn , Amine Ounajim , Guy Fagherazzi , Antonia Gasch-Illescas , Ben Braithwaite , Jean-François Thébaut","doi":"10.1016/j.deman.2023.100128","DOIUrl":null,"url":null,"abstract":"<div><p>Patient Reported Outcome Measures (PROMs) are recognized by health authorities as fundamental and can be evaluated by several questionnaires. The main complexity of evaluating PROMs in People with Diabetes (PwD), be it type 1 (PwT1D) or type 2 (PwT2D), is choosing the right tool (generic or specific) with the right constructs. This study explores the use of PROMs in PwD. The main objective was to compare generic and specific QoL PROMs in a diabetic population. The secondary objective was to assess potential overlaps of assessed constructs in the different PROMs frequently used in diabetes.</p><p>PRODIAB was an online quantitative survey conducted between January and February 2022. The scientific committee selected the following oft-used questionnaires: EuroQol 5-Dimensions 5-Level (EQ-5D-5L), Audit of Diabetes Dependent Quality of Life (ADDQOL), Treatment Burden Questionnaire (TBQ), Hospital Anxiety and-Depression Scale (HADS-A; HADS-D) and Patient-Health-Questionnaire-9 (PHQ-9). All PROMs used were validated in French.</p><p>Responses from 2,796 French PwD were analyzed. Compared to PwT2D, PwT1D reported a better general Quality of Life (QoL) on the EQ-5D-5L index (0.75 vs 0.66; <em>p</em> < 0.001) and a lower specific QoL on the ADDQOL (-2.8 vs -2.5; <em>p</em> < 0.001). Adjusted analysis showed that age was inversely associated with EQ-5D-5L index score (-0.11; <em>p</em> < 0.001) and a positively associated with ADDQOL score (0.14; <em>p</em> < 0.001). All PROMs were significantly correlated with each other and the HADS-A, HADS-D and PHQ9 (<em>r</em> 0.60 to 0.72) even more so. While principal component analyses suggested that all PROMs measured only one dimension (mental health) (eigenvalue=3.39; first dimension percentage of variance 56.5), adjusted analyses suggested that the EQ-5D-5L is not adequate for assessing the specific impact of diabetes on QoL.</p><p>Our study emphasizes the importance of identifying the constructs assessed by each PROM as well as the target population in order to choose the best-suited questionnaire type with the most appropriate constructs.</p></div>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"PRODIAB: Perspectives on the use of patient-reported outcome measures among diabetic patients\",\"authors\":\"Nicolas Naïditch , Coline Hehn , Amine Ounajim , Guy Fagherazzi , Antonia Gasch-Illescas , Ben Braithwaite , Jean-François Thébaut\",\"doi\":\"10.1016/j.deman.2023.100128\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Patient Reported Outcome Measures (PROMs) are recognized by health authorities as fundamental and can be evaluated by several questionnaires. The main complexity of evaluating PROMs in People with Diabetes (PwD), be it type 1 (PwT1D) or type 2 (PwT2D), is choosing the right tool (generic or specific) with the right constructs. This study explores the use of PROMs in PwD. The main objective was to compare generic and specific QoL PROMs in a diabetic population. The secondary objective was to assess potential overlaps of assessed constructs in the different PROMs frequently used in diabetes.</p><p>PRODIAB was an online quantitative survey conducted between January and February 2022. The scientific committee selected the following oft-used questionnaires: EuroQol 5-Dimensions 5-Level (EQ-5D-5L), Audit of Diabetes Dependent Quality of Life (ADDQOL), Treatment Burden Questionnaire (TBQ), Hospital Anxiety and-Depression Scale (HADS-A; HADS-D) and Patient-Health-Questionnaire-9 (PHQ-9). All PROMs used were validated in French.</p><p>Responses from 2,796 French PwD were analyzed. Compared to PwT2D, PwT1D reported a better general Quality of Life (QoL) on the EQ-5D-5L index (0.75 vs 0.66; <em>p</em> < 0.001) and a lower specific QoL on the ADDQOL (-2.8 vs -2.5; <em>p</em> < 0.001). Adjusted analysis showed that age was inversely associated with EQ-5D-5L index score (-0.11; <em>p</em> < 0.001) and a positively associated with ADDQOL score (0.14; <em>p</em> < 0.001). All PROMs were significantly correlated with each other and the HADS-A, HADS-D and PHQ9 (<em>r</em> 0.60 to 0.72) even more so. While principal component analyses suggested that all PROMs measured only one dimension (mental health) (eigenvalue=3.39; first dimension percentage of variance 56.5), adjusted analyses suggested that the EQ-5D-5L is not adequate for assessing the specific impact of diabetes on QoL.</p><p>Our study emphasizes the importance of identifying the constructs assessed by each PROM as well as the target population in order to choose the best-suited questionnaire type with the most appropriate constructs.</p></div>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S266697062300001X\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S266697062300001X","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
PRODIAB: Perspectives on the use of patient-reported outcome measures among diabetic patients
Patient Reported Outcome Measures (PROMs) are recognized by health authorities as fundamental and can be evaluated by several questionnaires. The main complexity of evaluating PROMs in People with Diabetes (PwD), be it type 1 (PwT1D) or type 2 (PwT2D), is choosing the right tool (generic or specific) with the right constructs. This study explores the use of PROMs in PwD. The main objective was to compare generic and specific QoL PROMs in a diabetic population. The secondary objective was to assess potential overlaps of assessed constructs in the different PROMs frequently used in diabetes.
PRODIAB was an online quantitative survey conducted between January and February 2022. The scientific committee selected the following oft-used questionnaires: EuroQol 5-Dimensions 5-Level (EQ-5D-5L), Audit of Diabetes Dependent Quality of Life (ADDQOL), Treatment Burden Questionnaire (TBQ), Hospital Anxiety and-Depression Scale (HADS-A; HADS-D) and Patient-Health-Questionnaire-9 (PHQ-9). All PROMs used were validated in French.
Responses from 2,796 French PwD were analyzed. Compared to PwT2D, PwT1D reported a better general Quality of Life (QoL) on the EQ-5D-5L index (0.75 vs 0.66; p < 0.001) and a lower specific QoL on the ADDQOL (-2.8 vs -2.5; p < 0.001). Adjusted analysis showed that age was inversely associated with EQ-5D-5L index score (-0.11; p < 0.001) and a positively associated with ADDQOL score (0.14; p < 0.001). All PROMs were significantly correlated with each other and the HADS-A, HADS-D and PHQ9 (r 0.60 to 0.72) even more so. While principal component analyses suggested that all PROMs measured only one dimension (mental health) (eigenvalue=3.39; first dimension percentage of variance 56.5), adjusted analyses suggested that the EQ-5D-5L is not adequate for assessing the specific impact of diabetes on QoL.
Our study emphasizes the importance of identifying the constructs assessed by each PROM as well as the target population in order to choose the best-suited questionnaire type with the most appropriate constructs.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
