以亚麻、五味子、木犀总黄酮为主要成分的降血糖新配方的优化设计

Hamza Mechchate, Wessal Ouedrhiri, I. Es-safi, Amal Amaghnouje, F. Jawhari, D. Bousta
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引用次数: 20

摘要

黄酮类化合物是一类具有可变酚类结构的天然化学物质,长期以来被认为具有健康优势,近年来在治疗糖尿病和高血糖方面引起了研究人员的关注。本研究的目的是利用三种植物黄酮类化合物:Linum usitatissimum L.种子(FLU), Coriandrum sativum L.种子(FCS)和Olea europaea var. sylvestris叶片(FOE)的组合开发一种新的降糖配方,该配方基于混合设计实验方法,该方法可以产生混合物中每种成分的最有效比例,而不是采用试错法。试验前进行亚急性毒性研究,确定安全有效的剂量。采用口服葡萄糖耐量试验(OGTT)评估这些提取物及其组合对瑞士白化小鼠的降糖作用。有效、安全的剂量为25mg /kg,所有制剂均采用25mg /kg。结果表明,二元和三元组合的协同效应最为显著。最有效的最佳组合是37% FLU, 20% FCS和43% FOE。本研究的血糖变化(GV)混合设计和预测模型可用于工业水平,以开发安全有效的新型降糖和降糖配方。
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Optimization of a New Antihyperglycemic Formulation Using a Mixture of Linum usitatissimum L., Coriandrum sativum L., and Olea europaea var. sylvestris Flavonoids: A Mixture Design Approach
Flavonoids are a class of natural chemicals with variable phenolic structures that have long been recognized for their health advantages, they have recently attracted researchers’ attention for treating diabetes and hyperglycemia. The goal of this research is to develop a novel antihyperglycemic formulation using a combination of three plant flavonoids: Linum usitatissimum L. seeds (FLU), Coriandrum sativum L. seeds (FCS), and Olea europaea var. sylvestris leaves (FOE) based on a mixture design experiment approach which generates the most effective ratio of each component in a mixture instead of the trial-and-error method. Prior to the test, sub-acute toxicity research was conducted to establish a safe and effective dosage. The Oral Glucose Tolerance Test (OGTT) was used to assess the antihyperglycemic impact of these extracts and their combinations in Swiss albino mice. The dose that showed efficacy and safety was 25 mg/kg, which was utilized in all formulations. According to the results, the binary and ternary combinations showed the most significant synergetic effects. The optimum combination with the most potent effect was 37% FLU, 20% FCS, and 43% FOE. This study’s mixture design and prediction model for glycemic variation (GV) may be utilized at an industrial level to develop a novel antidiabetic and antihyperglycemic formulation that is safe and effective.
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