五种不常见西番莲属植物的行为药理学表现出镇静和类似焦虑的潜力。

M. Sakalem, R. Tabach, Miriane de Oliveira, E. Carlini
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引用次数: 0

摘要

背景西番莲属有500多种,虽然其中一些西番莲在民间医学中以其抗焦虑作用而闻名,但对其他可能具有药用作用的西番莲科代表植物却知之甚少。目的在本研究中,我们对五种很少被研究的西番莲进行了种间药理学比较,这些西番莲都原产于巴西:P.bahiensis、P.coccinea、P.quadraularis、P.sidaefolia和P.vitifolia。方法在行为测试前给小鼠服用提取物,包括一般药理学筛选和抗焦虑样作用研究。结果三个种(P.coccinea、P.quadraularis和P.sidaefolia)诱导小鼠运动活性降低;球虫也降低了睡眠的潜伏期。重要的是,这些物种都没有干扰运动协调。即使在较高剂量下,口服也不会引起严重的毒性迹象。关于焦虑样特征,在Holeboard测试中,P.sidaefolia以与阳性对照Passiflora incarnata相似的方式减少了焦虑样行为,同时不影响总的运动性。结论这些结果表明,P.coccinea、P.quadraularis和P.sidaefolia降低了小鼠的一般活性,并赋予这三个物种平静/镇静的潜力,这一点必须在未来的研究中进一步阐明。
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Behavioral Pharmacology of Five Uncommon Passiflora Species Indicates Sedative and Anxiolytic-like Potential.
BACKGROUND There are over 500 species in the Passiflora genus, and while some of them are very well known in folk medicine for their anxiolytic effects, very little is known for the other genus representants, which could also present medicinal effects. OBJECTIVE In this study, we performed an interspecific pharmacological comparison of five little investigated Passiflora species, all native to Brazil: P. bahiensis, P. coccinea, P. quadrangularis, P. sidaefolia, and P. vitifolia. METHOD Extracts were administered to mice before behavioral testing, which included a general pharmacological screening and anxiolytic-like effect investigation. RESULTS Three of the species [P. coccinea, P. quadrangularis, and P. sidaefolia] induced a decrease in locomotor activity of mice; P. coccinea also reduced the latency to sleep. Importantly, none of the species interfered with motor coordination. Oral administration evoked no severe signs of toxicity even at higher doses. Regarding the anxiolytic-like profile, P. sidaefolia reduced the anxious-like behavior in the Holeboard test in a similar way to the positive control, Passiflora incarnata, while not affecting total motricity. CONCLUSION These results indicate that P. coccinea, P. quadrangularis, and P. sidaefolia reduced the general activity of mice and confer a calmative/sedative potential to these three species, which must be further elucidated by future investigations.
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来源期刊
Central nervous system agents in medicinal chemistry
Central nervous system agents in medicinal chemistry Psychology-Neuropsychology and Physiological Psychology
CiteScore
2.10
自引率
0.00%
发文量
21
期刊介绍: Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents. Containing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.
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