Rakel Olinda Macedo da Silva, M. K. D. N. Silva Leandro, A. C. Araújo, José Walber Gonçalves Castro, Orlando de Menezes Dantas Junior, Raíra Justino Oliveira Costa, Luciely Leite Pinto, Jaime Ribeiro-Fil-ho, L. E. da Silva, W. Amaral, C. Deschamps, E. F. Matias, H. Coutinho
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引用次数: 0
摘要
摘要本研究旨在研究从巴西尤金亚(Eugenia brasiliensis Lam, EOEb)和派柏(Piper mosenii C. DC)叶中提取的精油对抗生素的增强作用。(EOPm)对多重耐药菌株大肠杆菌06和金黄色葡萄球菌10。采用加氢蒸馏法提取精油，用肉汤微量稀释法测定最小抑菌浓度(MIC)。EOEb分别增强了诺氟沙星和红霉素对金黄色葡萄球菌和大肠杆菌的活性。在相同条件下，发现EOPm能增强庆大霉素和红霉素对大肠杆菌的作用。值得注意的是，这是迄今为止首次报道这些提取物增强传统抗生素抗菌活性的能力的研究。
Potentiation of the Antibiotic Activity by the Essential Oils of Eugenia brasiliensis Lam. and Piper mosenii C. DC.
Abstract The present study aimed to investigate the antibiotic-enhancing activity of the essential oils obtained from the leaves of Eugenia brasiliensis Lam (EOEb) and Piper mosenii C. DC. (EOPm) against multiresistant strains of Escherichia coli 06 and Staphylococcus aureus 10. The essential oils were obtained by hydrodistillation, and the minimum inhibitory concentrations (MIC) were determined through the broth microdilution method. The EOEb enhanced the activities of norfloxacin and erythromycin against Staphylococcus aureus and Escherichia coli, respectively. At the same conditions, the EOPm was found to potentiate the effects of gentamicin and erythromycin against E. coli. Of note, this is the first study to date that has reported the ability of these extracts to enhance the antibacterial activity of conventional antibiotics.
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