igg4相关自身免疫性胰腺炎的诊断、治疗和预后研究进展

Xin-Tian He, B. Sun, Y. Nie, Wen Zhang
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摘要

免疫球蛋白G4 (IgG4)相关自身免疫性胰腺炎(AIP),也称为“1型AIP”,是一种罕见的慢性纤维炎性疾病,表现为梗阻性黄疸和胰腺肿大,通常伴有胰腺外器官受累。对igg4相关AIP的认识正在逐步加深。在本文中,我们主要根据近5年来发表的病例报告、队列研究、荟萃分析和指南,对本病的基本概念、常见临床表现以及诊断、治疗策略和预后等方面的新进展进行综述。诸如诊断标记物、复发危险因素和更有效的治疗等问题仍需进一步研究。
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Recent advances in diagnosis, treatment, and prognosis of IgG4-related autoimmune pancreatitis: a narrative review
Immunoglobulin G4 (IgG4)-related autoimmune pancreatitis (AIP), also known as “type 1 AIP,” is a rare, chronic, and fibroinflammatory disease manifested as obstructive jaundice and enlargement of the pancreas, usually accompanied by extra-pancreatic organ involvement. The understanding of IgG4-related AIP is gradually deepening. In this review, we summarized the basic concepts, common clinical manifestations, and new progress of the disease including diagnostic, therapeutic strategies, and prognosis mainly based on published case reports, cohort studies, meta-analyses, and guidelines in the past 5 years. Issues such as diagnostic markers, risk factors for relapse, and more effective treatment still need to be further studied.
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