系统性红斑狼疮患者的抑郁、疼痛和健康相关生活质量

IF 2.3 Q2 RHEUMATOLOGY International Journal of Rheumatology Pub Date : 2022-05-05 DOI:10.1155/2022/6290736
N. Chalhoub, M. Luggen
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Sociodemographic data, Beck Depression Inventory (BDI II), SLE disease activity index (SLEDAI-2K), SLICC Damage Index (SLICC-DI), pain severity (10 cm visual analogue scale), cognitive function (Automated Neuropsychologic Assessment Metrics (ANAM)), and the physical (PCS) and mental (MCS) component scores of the Short Form Health Survey (SF-36) were recorded. Bivariate analysis identified potential associations of relevant variables with BDI II and SF-36. Regression analysis determined independent correlates with MSD, PCS, and MCS. Results Over 50% of subjects (50.5%) were African-American, 37.1% had a family income of ≤$20,000, and 31.3% had MSD. In the bivariate analysis, family income, SLEDAI-2K, cognitive function, and pain severity were associated with MSD. Using binary logistic regression, SLEDAI-2K and pain severity remained independently correlated with MSD (p = 0.004). 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引用次数: 5

摘要

目的系统性红斑狼疮(SLE)患者中有相当多的患者患有抑郁症,许多患者未经治疗。我们的目的是评估具有不同社会人口背景的多民族SLE患者中中度至重度抑郁症(MSD)的发生频率,确定与抑郁症相关的可改变因素,并确定抑郁症、疾病活动、损伤、认知功能和疼痛严重程度对健康相关生活质量(HRQoL)的影响。方法对99例SLE患者进行横断面研究。社会形态图数据、Beck抑郁量表(BDI-II)、SLE疾病活动指数(SLEDAI-2K)、SLICC损伤指数(SLICC-DI)、疼痛严重程度(10 cm视觉模拟量表)、认知功能(自动神经心理评估指标(ANAM))以及短期健康调查(SF-36)的身体(PCS)和心理(MCS)成分得分。双变量分析确定了相关变量与BDI II和SF-36的潜在关联。回归分析确定了与MSD、PCS和MCS的独立相关性。结果超过50%(50.5%)的受试者是非裔美国人,37.1%的受试对象的家庭收入≤20000美元,31.3%的受试人患有默沙东。在双变量分析中,家庭收入、SLEDAI-2K、认知功能和疼痛严重程度与MSD相关。使用二元逻辑回归,SLEDAI-2K和疼痛严重程度与MSD保持独立相关性(p=0.004)。在多元线性回归分析中,疼痛严重程度是PCS的唯一独立相关性(p<0.0001),而认知功能和BDI II是与MCS相关的主要因素(分别为p=0.020和p<0.00001)。结论在我们独特的人群中,疼痛严重程度和疾病活动性与MSD相关,具有潜在的可改变性,值得临床进一步关注。抑郁和疼痛会显著影响HRQoL,应积极治疗。
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Depression-, Pain-, and Health-Related Quality of Life in Patients with Systemic Lupus Erythematosus
Objectives A significant number of patients with systemic lupus erythematosus (SLE) have depression, and many are untreated. We aim to assess the frequency of moderate to severe depression (MSD) in a multiethnic group of SLE patients with different sociodemographic backgrounds, identify modifiable factors associated with depression, and determine the impact of depression, disease activity, damage, cognitive function, and pain severity on health-related quality of life (HRQoL). Methods Ninety-nine patients with SLE were evaluated in a cross-sectional study. Sociodemographic data, Beck Depression Inventory (BDI II), SLE disease activity index (SLEDAI-2K), SLICC Damage Index (SLICC-DI), pain severity (10 cm visual analogue scale), cognitive function (Automated Neuropsychologic Assessment Metrics (ANAM)), and the physical (PCS) and mental (MCS) component scores of the Short Form Health Survey (SF-36) were recorded. Bivariate analysis identified potential associations of relevant variables with BDI II and SF-36. Regression analysis determined independent correlates with MSD, PCS, and MCS. Results Over 50% of subjects (50.5%) were African-American, 37.1% had a family income of ≤$20,000, and 31.3% had MSD. In the bivariate analysis, family income, SLEDAI-2K, cognitive function, and pain severity were associated with MSD. Using binary logistic regression, SLEDAI-2K and pain severity remained independently correlated with MSD (p = 0.004). In the multiple linear regression analysis, pain severity was the only independent correlate of PCS (p < 0.0001), while cognitive function and BDI II were the main factors associated with MCS (p = 0.020 and p < 0.0001, respectively). Conclusion Pain severity and disease activity are associated with MSD in our unique population, are potentially modifiable, and deserve further attention in the clinic. Depression and pain significantly affect HRQoL and should be aggressively managed.
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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
9
审稿时长
24 weeks
期刊最新文献
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