饲喂3个月不同脂肪酸组成的高脂饲料对小鼠肾脏组织学及细胞应激和水电解质平衡相关基因表达的影响

IF 1.4 4区农林科学 Q3 AGRICULTURE, DAIRY & ANIMAL SCIENCE Journal of Animal and Feed Sciences Pub Date : 2023-06-22 DOI:10.22358/jafs/163179/2023

A. Wypych, A. Dunisławska, M. Grabowska, K. Michałek, M. Ożgo, K. Liput, A. Herosimczyk, E. Polawska, M. Pierzchała, A. Lepczynski

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引用次数: 1

摘要

西方饮食通常饱和脂肪酸含量高，n-3多不饱和脂肪酸（PUFA）含量低，已被确定为导致肥胖率上升的因素。长期食用高脂肪饮食（HFDs）也与患慢性肾脏疾病的风险增加有关。因此，我们假设HFDs中不同的脂肪酸组成会对肾脏微观结构和所选基因的表达模式产生不同的影响。瑞士韦伯斯特雄性小鼠（n=24）喂食小鼠标准食物（STD

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Effects of three-month feeding high-fat diets with different fatty acid composition on kidney histology and expression of genes related to cellular stress and water-electrolyte homeostasis in mice

. The Western diet, which is typically high in saturated fatty acids (SFAs) and low in n-3 polyunsaturated fatty acids (PUFAs), has been identified as a factor contributing to the growing obesity rate. Long-term consumption of high-fat diets (HFDs) has also been associated with increased risk of chronic kidney disease. Therefore, we hypothesized that different fatty acids composition in HFDs would differentially affect renal microstructure and expression pattern of selected genes. Swiss-Webster male mice (n = 24) were fed a standard chow for mice (STD

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来源期刊

Journal of Animal and Feed Sciences 农林科学-奶制品与动物科学

CiteScore

2.10

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Journal of Animal and Feed Sciences (JAFS, J. Anim. Feed Sci.) has been published by the Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences in Jabłonna (Poland) since 1991. It is a continuation of the Polish-language journal Roczniki Nauk Rolniczych. Seria B, Zootechniczna published by the Polish Academy of Sciences since 1969. JAFS is an international scientific journal published quarterly, about 40 papers per year including original papers, short communications and occasionally reviews. All papers are peer-reviewed and related to basic and applied researches in the field of animal breeding and genetics, physiology of nutrition, animal feeding, feed technology and food preservation. The journal distinguishes the multidisciplinary nature of physiological and nutritional sciences and so includes papers specialized in all fields connected with animal well-being, including molecular and cell biology and the emerging area of genetics.