加巴喷丁治疗烟酒使用障碍的研究综述

IF 1.4 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Open Access Journal of Clinical Trials Pub Date : 2020-09-01 DOI:10.2147/OAJCT.S257556
Gabriel C Quintero Garzola
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引用次数: 1

摘要

背景:酒精和烟草使用障碍是没有适当治疗的普遍健康问题。加巴喷丁被用于治疗不同的精神疾病,包括成瘾。方法:本文对加巴喷丁治疗烟酒使用障碍的研究进展进行综述。因此,使用“加巴喷丁”和“酒精”或“烟草”搜索PubMed数据库(1983年1月1日至2017年8月31日)。用英语写的动物和人类研究也包括在内。共有426条记录被确定,其中40篇文章符合入选标准并被纳入本综述。排除的主要原因是加巴喷丁不是感兴趣的干预措施或研究人群没有酒精/烟草滥用问题。此外,引言中还包括28篇参考文献,共计68篇参考文献。加巴喷丁治疗酒精/烟草使用问题的成功率是通过计算各研究的成功率来确定的:获得有利结果的调查总数除以针对每种特定疾病(如酒精或烟草依赖或其他)的调查总数。结果和讨论:加巴喷丁治疗酒精使用障碍的现有证据表明,这种治疗方法成功地缓解了与酒精滥用相关的问题,包括戒断症状、依赖和渴望。然而,需要更多的研究来确定加巴喷丁预防复发的有效性。此外,在得出加巴喷丁治疗烟草依赖的有效性的结论之前,还需要更多的数据。
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The Use of Gabapentin for the Treatment of Alcohol and Tobacco Use Disorders: A Review
Background: Alcohol and tobacco use disorders are pervasive health problems without adequate treatment. Gabapentin has been used for different psychiatric disorders, including addiction. Methods: In this article, the use of gabapentin for the treatment of alcohol and tobacco use disorders is reviewed. Accordingly, a database search of PubMed was performed (January 1, 1983–August 31, 2017), using the search terms “gabapentin” AND “alcohol” OR “tobacco”. Animal and human studies written in English were included. A total of 426 records were identified, and 40 articles met eligibility criteria and were included in this review. The main reasons for exclusion were gabapentin was not the intervention of interest or the study population did not have alcohol/tobacco abuse issues. Additionally, 28 references were included in the Introduction, for a total of 68 references. The success of gabapentin for treating alcohol/tobacco use problems was determined by calculating the success rate across studies: the total number of investigations with favorable results was divided by the total numbers of investigations for each specific disorder (eg, alcohol or tobacco dependence, or other). Results and Discussion: The available evidence on gabapentin for alcohol use disorder suggests that this treatment successfully alleviates problems related to alcohol abuse, including withdrawal symptoms, dependence, and cravings. However, more research is needed to determine the effectiveness of gabapentin for preventing relapse. Further, more data are required before a conclusion regarding gabapentin’s effectiveness for treating tobacco dependence.
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来源期刊
Open Access Journal of Clinical Trials
Open Access Journal of Clinical Trials MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
3.90
自引率
0.00%
发文量
2
审稿时长
16 weeks
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