{"title":"纵向研究的统计分析","authors":"Nan M. Laird","doi":"10.1111/insr.12523","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Longitudinal studies play a prominent role in research on growth, change and/or decline in individuals, and in characterising the environmental and social factors which influence change. The essential feature of a longitudinal study is taking repeated measures of an outcome on the same set of individuals at multiple timepoints, thereby allowing investigators to characterise within subject changes during the measurement period. This paper provides an overview of how the basic design features and analysis of longitudinal studies are related to other study designs, including longitudinal clinical trials as well as repeated measures studies. I summarise the use of the linear mixed model as described in Laird and Ware for the analysis of a broad class of designs and present some applications in health and medicine.</p>\n </div>","PeriodicalId":14479,"journal":{"name":"International Statistical Review","volume":"90 S1","pages":"S2-S16"},"PeriodicalIF":1.7000,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Statistical analysis of longitudinal studies\",\"authors\":\"Nan M. Laird\",\"doi\":\"10.1111/insr.12523\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>Longitudinal studies play a prominent role in research on growth, change and/or decline in individuals, and in characterising the environmental and social factors which influence change. The essential feature of a longitudinal study is taking repeated measures of an outcome on the same set of individuals at multiple timepoints, thereby allowing investigators to characterise within subject changes during the measurement period. This paper provides an overview of how the basic design features and analysis of longitudinal studies are related to other study designs, including longitudinal clinical trials as well as repeated measures studies. I summarise the use of the linear mixed model as described in Laird and Ware for the analysis of a broad class of designs and present some applications in health and medicine.</p>\\n </div>\",\"PeriodicalId\":14479,\"journal\":{\"name\":\"International Statistical Review\",\"volume\":\"90 S1\",\"pages\":\"S2-S16\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2022-10-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Statistical Review\",\"FirstCategoryId\":\"100\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/insr.12523\",\"RegionNum\":3,\"RegionCategory\":\"数学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"STATISTICS & PROBABILITY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Statistical Review","FirstCategoryId":"100","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/insr.12523","RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"STATISTICS & PROBABILITY","Score":null,"Total":0}
Longitudinal studies play a prominent role in research on growth, change and/or decline in individuals, and in characterising the environmental and social factors which influence change. The essential feature of a longitudinal study is taking repeated measures of an outcome on the same set of individuals at multiple timepoints, thereby allowing investigators to characterise within subject changes during the measurement period. This paper provides an overview of how the basic design features and analysis of longitudinal studies are related to other study designs, including longitudinal clinical trials as well as repeated measures studies. I summarise the use of the linear mixed model as described in Laird and Ware for the analysis of a broad class of designs and present some applications in health and medicine.
期刊介绍:
International Statistical Review is the flagship journal of the International Statistical Institute (ISI) and of its family of Associations. It publishes papers of broad and general interest in statistics and probability. The term Review is to be interpreted broadly. The types of papers that are suitable for publication include (but are not limited to) the following: reviews/surveys of significant developments in theory, methodology, statistical computing and graphics, statistical education, and application areas; tutorials on important topics; expository papers on emerging areas of research or application; papers describing new developments and/or challenges in relevant areas; papers addressing foundational issues; papers on the history of statistics and probability; white papers on topics of importance to the profession or society; and historical assessment of seminal papers in the field and their impact.