{"title":"具有非进展者行为改变的病毒抗性HIV-1模型分析","authors":"Musa Rabiu, R. Willie, N. Parumasur","doi":"10.11145/j.biomath.2020.06.143","DOIUrl":null,"url":null,"abstract":"We develop a virus-resistant HIV-1 mathematical model with behavioural change in HIV-1 resistant non-progressors. The model has both disease-free and endemic equilibrium points that are proved to be locally asymptotically stable depending on the value of the associated reproduction numbers. In both models, a non-linear Goh{Volterra Lyapunov function was used to prove that the endemic equilibrium point is globally asymptotically stable for special case while the method of Castillo-Chavez was used to prove the global asymptotic stability of the disease-free equilibrium point. In both the analytic and numerical results, this study shows that in the context of resistance to HIV/AIDS, total abstinence can also play an important role in protection against this notorious infectious disease.","PeriodicalId":52247,"journal":{"name":"Biomath","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":"{\"title\":\"Analysis of a virus-resistant HIV-1 model with behavior change in non-progressors\",\"authors\":\"Musa Rabiu, R. Willie, N. Parumasur\",\"doi\":\"10.11145/j.biomath.2020.06.143\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We develop a virus-resistant HIV-1 mathematical model with behavioural change in HIV-1 resistant non-progressors. The model has both disease-free and endemic equilibrium points that are proved to be locally asymptotically stable depending on the value of the associated reproduction numbers. In both models, a non-linear Goh{Volterra Lyapunov function was used to prove that the endemic equilibrium point is globally asymptotically stable for special case while the method of Castillo-Chavez was used to prove the global asymptotic stability of the disease-free equilibrium point. In both the analytic and numerical results, this study shows that in the context of resistance to HIV/AIDS, total abstinence can also play an important role in protection against this notorious infectious disease.\",\"PeriodicalId\":52247,\"journal\":{\"name\":\"Biomath\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-08-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomath\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.11145/j.biomath.2020.06.143\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Agricultural and Biological Sciences\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomath","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.11145/j.biomath.2020.06.143","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Agricultural and Biological Sciences","Score":null,"Total":0}
Analysis of a virus-resistant HIV-1 model with behavior change in non-progressors
We develop a virus-resistant HIV-1 mathematical model with behavioural change in HIV-1 resistant non-progressors. The model has both disease-free and endemic equilibrium points that are proved to be locally asymptotically stable depending on the value of the associated reproduction numbers. In both models, a non-linear Goh{Volterra Lyapunov function was used to prove that the endemic equilibrium point is globally asymptotically stable for special case while the method of Castillo-Chavez was used to prove the global asymptotic stability of the disease-free equilibrium point. In both the analytic and numerical results, this study shows that in the context of resistance to HIV/AIDS, total abstinence can also play an important role in protection against this notorious infectious disease.