氟立班色林治疗性欲减退:纳入治疗

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2017-01-01 DOI:10.1177/2040622316679933
F. Gelman, J. Atrio
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引用次数: 22

摘要

更年期前后女性性兴趣的病理生理学、诊断和治疗为患者和医生提供了一个复杂的领域。Flibanserin是美国食品药品监督管理局于2015年8月批准的第一种治疗绝经前女性低活动性性欲障碍(HSDD)的药物。绝经后妇女的副作用、禁忌症和未经批准都是局限性的,围绕患者和医生的知识和获取途径的问题也是如此。睾酮、丁螺环酮、西地那非、安非他酮、布瑞黑肽以及草药(herbal vX或Tribulus terrestris)已证明对患有性功能障碍障碍的女性具有一定的临床益处。然而,试验在设计、给药或可推广性方面存在显著限制。非药物认知行为疗法、正念冥想、盆底疗法和阴蒂刺激器也是女性可能追求的干预措施。本文将探讨有关这些治疗模式的临床数据,以引起人们对女性HSDD问题的关注,提供当前研究的概述,并促使提供者在自己和患者之间展开讨论。
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Flibanserin for hypoactive sexual desire disorder: place in therapy
The pathophysiology, diagnosis and treatment of female sexual interest in pre- and post-menopausal women present a complex arena for patients and physicians to navigate. Flibanserin was the first pharmacologic treatment, approved by the United States Food and Drug Administration in August 2015, for hypoactive sexual desire disorder (HSDD) in premenopausal women. Side effects, contraindications and lack of approval in postmenopausal women are all limitations, as are issues surrounding patient and physician knowledge and access. Testosterone, buspirone, sildenafil, bupropion, bremelanotide, as well as herbal medications (Herbal vX or Tribulus terrestris) have demonstrated some clinical benefit in women with sexual dysfunction disorders however, trials have significant design, dosing or generalizability limitations. Nonpharmaceutical cognitive behavioral therapy, mindfulness meditation, pelvic floor therapy, and clitoral stimulators are also interventions women may pursue. This manuscript will explore the clinical data regarding these therapeutic modalities so as to bring attention to this issue of female HSDD, to offer an overview of current research, and to incite providers to initiate discussion among themselves and their patients.
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来源期刊
CiteScore
7.20
自引率
4.30%
发文量
567
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