单细胞分化轨迹定义人类皮肤T细胞淋巴瘤的早期阶段

J. Cerapio, M. Perrier, F. Pont, C. Laurent, Stéphane Bertani, J. Fournié
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引用次数: 0

摘要

目的:本文的目的是详细描述一名患有γδ亚型原发性皮肤T细胞淋巴瘤(γδCTCL)的成年患者的γδT淋巴细胞。结果:在CTCL斑块-斑块进展过程中,γδT细胞的TCRVγnon9亚群从幼稚T细胞(Tn)和中央记忆T细胞(Tcm)分化为丰富的效应记忆T细胞,而其他皮肤γδT和CD8 T细胞保持不变。结论:这种转录组转换是TCRVγnon9γδT亚型CTCL样进展的基础,并为治疗这些疾病提供了新的途径。
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Single-cell differentiation trajectories define early stages of a human cutaneous T-cell lymphoma
Aim: The aim of this article is to characterize in detail the γδ T lymphocytes from an adult patient with primary cutaneous T-cell lymphoma of γδ subtype (γδ CTCL). Methods: Here this article reports trajectory mapping on high-resolution differentiation trajectories of γδ T lymphocytes digitally extracted from a scRNAseq dataset. Results: In the patch-to-plaque progression of CTCL, the TCRVγnon9 subset of γδ T cells differentiated from naive T cells (Tn) and central memory T cells (Tcm) to abundant effector memory T cells (Tem) while other cutaneous γδ T and CD8 T cells remained unchanged. Conclusions: This transcriptomic switch underlies the emergence of a CTCL-like progression of the TCRVγnon9 γδ T subtype and suggests new routes for treating these diseases.
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