γ-干扰素治疗皮肤T细胞淋巴瘤后可逆性心肌病2例报告

Joseph S. Durgin , Neha N. Jariwala , Alain H. Rook , Juan M. Ortega-Legaspi
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引用次数: 0

摘要

干扰素是一种广泛表达的细胞因子,具有强大的抗病毒和抗肿瘤活性。作为治疗药物,干扰素已被证明对治疗各种癌症、慢性感染和自身免疫性疾病有用。然而,干扰素治疗有众所周知的副作用,包括流感样症状、抑郁、触发自身免疫现象和剂量依赖性细胞减少。在本报告中,我们描述了两例充血性心力衰竭发生后,干扰素γ (II型干扰素)治疗晚期皮肤T细胞淋巴瘤。根据现有的机制研究,干扰素对自身免疫的增强和对心肌的直接细胞毒性作用可能是干扰素治疗这种不常见的不良反应的原因。
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Reversible cardiomyopathy after interferon-gamma for cutaneous T cell lymphoma: A report of two cases

Interferons are widely expressed cytokines that possess potent anti-viral and anti-tumor activity. As therapeutic agents, interferons have proven useful in treating assorted cancers, chronic infections, and autoimmune disease. However, interferon therapy has well-known adverse effects, including flu-like symptoms, depression, triggering of autoimmune phenomena, and dose-dependent cytopenias. In this report, we describe two cases of congestive heart failure occurring after treatment with interferon-gamma (a type II interferon) for advanced cutaneous T cell lymphoma. Based on existing mechanistic studies, both the potentiation of autoimmunity and the direct cytotoxic effects of interferons on the myocardium may account for this uncommon adverse effect of interferon therapy.

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