祖母在怀孕期间吸烟与孙辈极度厌恶苦味有关

IF 4.8 Q1 GENETICS & HEREDITY Environmental Epigenetics Pub Date : 2022-02-16 DOI:10.1093/eep/dvac003
J. Golding, M. Pembrey, Steven Gregory, M. Suderman, Yasmin Iles-Caven, K. Northstone
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引用次数: 0

摘要

摘要尽管在实验文献中有许多一代人的环境暴露影响下一代人表型的例子,但很少有研究能够评估这种关联是否发生在人类身上。然而,雅芳父母和子女纵向研究(ALSPAC)已经能够确定祖父母的暴露与孙辈的发育之间是否存在关联。我们的几项研究,包括对大声噪音的敏感性,已经表明祖母在怀孕期间吸烟与孙子的表型之间存在关联。这些结果大多与孙子的性别以及产前(即怀孕期间)吸烟是发生在母亲还是祖母身上有关。在这里,我们使用了ALSPAC指数儿童的祖母在产前吸烟的祖先数据,以检查对孙子检测PROP苦味的能力的可能影响(6 正丙基硫氧嘧啶),区分10%的“极端味觉者”和其余人群(总n = 4656名儿童)。我们发现,祖母(而非外祖母)在怀孕期间吸烟的孙子孙女比不吸烟的祖母更有可能成为极端的品尝者[比值比(OR)1.28;95%置信区间(CI)1.03,1.59],孙女(OR 1.42;95%CI 1.03,1.95)比孙子孙女(OR 1.18;95%CI 0.88,1.60)更有可能成为这种情况已经发现父亲的胎儿暴露和孙女的发育还有其他几种结果,这表明应该进行调查来调查可能的机制。
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Paternal grandmother’s smoking in pregnancy is associated with extreme aversion to bitter taste in their grandchildren
Abstract Although there are many examples in the experimental literature of an environmental exposure in one generation impacting the phenotypes of subsequent generations, there are few studies that can assess whether such associations occur in humans. The Avon Longitudinal Study of Parents and Children (ALSPAC) has, however, been able to determine whether there are associations between grandparental exposures and their grandchildren’s development. Several of our studies, including sensitivity to loud noise, have shown associations between a grandmother smoking in pregnancy and the phenotype of the grandchild. These results were mostly specific to the sex of the grandchild and to whether the prenatal (i.e. during pregnancy) smoking occurred in the maternal or paternal grandmother. Here, we have used ancestral data on prenatal smoking among the grandmothers of the ALSPAC index children to examine possible effects on the grandchild’s ability to detect the bitter taste of PROP (6 n-propylthiouracil), distinguishing between the 10% deemed ‘extreme tasters’, and the rest of the population (total N = 4656 children). We showed that grandchildren whose paternal (but not maternal) grandmothers had smoked in pregnancy were more likely than those of non-smoking grandmothers to be extreme tasters [odds ratio (OR) 1.28; 95% confidence interval (CI) 1.03, 1.59] and that this was more likely in granddaughters (OR 1.42; 95% CI 1.03, 1.95) than grandsons (OR 1.18; 95% CI 0.88, 1.60). This pattern of association between paternal foetal exposure and the granddaughter’s development has been found with several other outcomes, suggesting that investigations should be undertaken to investigate possible mechanisms.
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来源期刊
Environmental Epigenetics
Environmental Epigenetics GENETICS & HEREDITY-
CiteScore
6.50
自引率
5.30%
发文量
0
审稿时长
17 weeks
期刊最新文献
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