{"title":"皮肤微生物群和皮肤屏障","authors":"Ming-Yang Wu, Xu Yao","doi":"10.1097/jd9.0000000000000334","DOIUrl":null,"url":null,"abstract":"The skin constitutes the primary barrier between the human body and the external environment. The skin microbiome plays an important role in the microecosystem on the skin surface and mediates multiple facets of the skin barrier function, including physical, chemical, microbial, and immune barriers. In this review, we discuss the host–microbiota interactions in barrier maintenance and disruption, implications for skin disorders such as atopic dermatitis, psoriasis, and rosacea, and the latest strategies for targeting the skin microbiota to improve the skin barrier.","PeriodicalId":34265,"journal":{"name":"International Journal of Dermatology and Venerology","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Skin Microbiota and the Skin Barrier\",\"authors\":\"Ming-Yang Wu, Xu Yao\",\"doi\":\"10.1097/jd9.0000000000000334\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The skin constitutes the primary barrier between the human body and the external environment. The skin microbiome plays an important role in the microecosystem on the skin surface and mediates multiple facets of the skin barrier function, including physical, chemical, microbial, and immune barriers. In this review, we discuss the host–microbiota interactions in barrier maintenance and disruption, implications for skin disorders such as atopic dermatitis, psoriasis, and rosacea, and the latest strategies for targeting the skin microbiota to improve the skin barrier.\",\"PeriodicalId\":34265,\"journal\":{\"name\":\"International Journal of Dermatology and Venerology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-08-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Dermatology and Venerology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/jd9.0000000000000334\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Dermatology and Venerology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/jd9.0000000000000334","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
The skin constitutes the primary barrier between the human body and the external environment. The skin microbiome plays an important role in the microecosystem on the skin surface and mediates multiple facets of the skin barrier function, including physical, chemical, microbial, and immune barriers. In this review, we discuss the host–microbiota interactions in barrier maintenance and disruption, implications for skin disorders such as atopic dermatitis, psoriasis, and rosacea, and the latest strategies for targeting the skin microbiota to improve the skin barrier.
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