Effect of quercetin on myocardial potency of curcumin against ischemia reperfusion induced myocardial toxicity

Background

Curcumin (CUR) is a well established cardioprotective phytoconstituent, but the poor bioavailability associated with it is providing a scope to do further research to improvise therapeutic efficacy of CUR. The present study was designed to address this challenge by combining with bio-enhancer like Quercetin (QUE) against ischemia reperfusion injury (IRI) induced myocardial toxicity in rats.

Materials and Methods

Rats (n = 8) were treated with CUR (200 mg/kg, p.o.) alone and combination of CUR (200 mg/kg, p.o.) and QUE (10 mg/kg, p.o.) for 30 days. Twenty four hour after last treatment Ischemia reperfusion injury was induced by modified Lagendorff apparatus, and the effect of different treatments was evaluated by percentage recovery in terms of heart rate and developed tension, biomarkers, heart tissue antioxidant levels and histopathological examination. Influence of QUE on pharmacokinetic of CUR was studied by HPLC method. Results obtained were assessed by one‑way analysis of variance followed by Tukey–Karmer multiple comparison test.

Results

CUR and QUE demonstrated significant myocardial potency compared to CUR alone‑treated group. Significant increase in bioavailability and half life, along with significant decrease in clearance was observed for CUR in combination group compared to CUR alone treated group.

Conclusion

From this study it can be concluded that combination of CUR and QUE exhibited profound protection compared to CUR alone treated group against IRI induced myocardial toxicity. Findings of pharmacokinetic interaction justified the results of pharmacodynamic interaction.