人源嵌合抗原受体(CAR) T细胞

Journal of cancer immunology Pub Date : 2021-12-31 DOI:10.33696/cancerimmunol.3.055

Pouya Safarzadeh Kozani, Pooria Safarzadeh Kozani, R. O’Connor

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引用次数: 6

摘要

T细胞以独特的抗原激活，在T细胞中激活一个主要的复杂嵌合体，作为抗原识别片段的单链可变片段域(scFv)和它的ζ链的TCR/CD3模块化重组，细胞内CD3 ζ以T细胞活化后抗原接合。它的起源嵌合抗原受体(CARs)用于临床这非常，CD3与CD3或生长因子受体结合蛋白的最佳结构重组

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Humanized Chimeric Antigen Receptor (CAR) T cells

T cells to unique antigens, the T-cell activation in a major complex chimeric as of the antigen recognition moiety to a single-chain variable fragment domain (scFv) and it the ζ chain of the TCR/CD3 modular recombinant, the intracellular CD3 ζ to T-cell activation following antigen engagement. it the origin of the chimeric antigen receptors (CARs) used clinically to of this very that CD3 with CD3 or growth factor receptor-bound protein optimal structural reconfigurations

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Journal of cancer immunology

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