脂多糖对母牛原始卵巢卵泡活化和凋亡的影响

IF 0.4 4区农林科学 Q4 VETERINARY SCIENCES Arquivo Brasileiro De Medicina Veterinaria E Zootecnia Pub Date : 2023-06-01 DOI:10.1590/1678-4162-12848

A. Maffi, J. Rincón, A. Barbosa, M. A. Weiller, R. Mondadori, B. Gasperin, M. Rovani, L. Cruz, K. C. Freitas, A. Schneider, M. N. Corrêa, J. Feijó, F. Pino, V. Rabassa, L. Marins, C. Brauner

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引用次数: 0

摘要

摘要本研究旨在探讨脂多糖(LPS)对原始卵泡活化和凋亡的影响。在卵泡总数和不同类型的卵泡中没有差异。此外，LPS攻击没有调节与卵巢储备(HAM)、卵母细胞存活(Survivin)、激活率(Pten、KIT、KITL1、KITL2、AKT1、SIRT1)和卵泡异常相关的基因的表达。因此，间隔24h的LPS暴露对激活率和原始卵泡异常没有影响，对抗凋亡基因以及与卵巢储备、卵母细胞存活、激活率和原始卵泡异常相关基因的表达也没有影响。

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Lipopolysaccharide effects on activation and apoptosis of primordial ovarian follicles in heifers

ABSTRACT The objective of the present study was to evaluate the effect of lipopolysaccharide (LPS) administration on activation and apoptosis of primordial follicles. There was no difference in the total number of follicles as well as in the different types of follicles. Furthermore, the LPS challenge didn’t modulate the expression of genes related with ovarian reserve (HAM), oocyte survival (Survivin), activation rate (Pten, KIT, KITL1, KITL2, AKT1, SIRT1), and follicular abnormalities. Therefore, the LPS exposure with 24h interval had no effect on activation rate and primordial follicles abnormalities, and also had no effect on expression of anti-apoptotic genes and genes related with ovarian reserve, oocyte survival, activation rate, and primordial follicles abnormalities.

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来源期刊

Arquivo Brasileiro De Medicina Veterinaria E Zootecnia 农林科学-兽医学

CiteScore

0.80

自引率

25.00%

发文量

111

审稿时长

9-18 weeks

期刊介绍： Publica artigos originais de pesquisa sobre temas de medicina veterinária, zootecnia, tecnologia e inspeção de produtos de origem animal e áreas afins relacionadas com a produção animal. Atualmente a revista mantém 628 permutas (419 internacionais e 209 nacionais), sendo um verdadeiro suporte para o recebimento de periódicos pela Biblioteca da Escola. A partir de 1999, a Escola de Veterinária delegou à FEP MVZ Editora o encargo do gerenciamento e edição de todas suas publicações, inclusive do Arquivo, ficando somente com o apoio logístico (instalações, equipamentos, pessoal etc.). O apoio financeiro é exercido pelo CNPq/FINEP e pela própria FEP MVZ.