给予胶原肽可防止博莱霉素治疗小鼠肺纤维化的进展

Minami Yoshihara, Chisaki Asatsuma, Ayuna Masuko, Keiya Iwaasa, Yuki Saito-Matsuzawa, H. Sone, S. Kamiyama
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摘要

胶原蛋白肽(CPs)是一种食物来源的肽,具有多种生物活性。本研究探讨了CP对博来霉素(BLM)治疗小鼠肺纤维化的影响。C57BL/6J小鼠皮下注射BLM 2周,随后给予含25 mg/g鸡爪CP的实验饮食3周。补充CP抑制了BLM小鼠肺重量的增加和肺结构的破坏。blm处理的小鼠也表现出更高的羟脯氨酸含量和肺中I型和III型胶原亚基基因表达水平的增加。补充粗蛋白质对这些胶原蛋白相关因子没有影响;然而,它显著抑制了blm处理小鼠肺中纤维连接蛋白和炎症相关分子的基因表达。这些发现表明,CP可作为抗炎剂预防肺纤维化的发生。
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Administration of Collagen Peptide Prevents the Progression of Pulmonary Fibrosis in Bleomycin-Treated Mice
Collagen peptides (CPs) are food-derived peptides that possess a variety of bioactive properties. Our study investigates the effects of CP on pulmonary fibrosis in bleomycin (BLM)-treated mice. C57BL/6J mice were subcutaneously injected with BLM for two weeks followed by a three-week experimental diet containing 25 mg/g of CP derived from chicken feet. Supplementation with CP suppressed the increase in lung weight and disruption of lung architecture observed in mice treated with BLM. BLM-treated mice also exhibited higher hydroxyproline content and increased expression levels of type I and III collagen subunit genes in the lungs. CP supplementation exerted no effect on these collagen-related factors; however, it significantly suppressed the gene expression of fibronectin and inflammation-related molecules in the lungs of BLM-treated mice. These findings suggest that CP administration prevents the development of pulmonary fibrosis by acting as an anti-inflammatory agent.
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