牛皮癣及其与代谢综合征的关系:在印度南部半城市地区三级保健中心的病例对照研究

Akshay Samagani, H. Yadalla, P. Belliappa
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摘要

背景:代谢综合征(MS)与牛皮癣等皮肤病有关。它们有共同的炎症途径,因此相互影响。目的:估计银屑病患者中多发性硬化症的患病率及其个体成分与对照组的患病率,并比较银屑病患者与非银屑病患者的特征。材料和方法:对100例临床诊断为慢性斑块型银屑病的患者进行多发性硬化症患病率评估,并与年龄和性别匹配的对照组进行比较。结果:研究人群属于半城市地区,社会经济地位较低。银屑病病例以男性为主,年龄以31 ~ 40岁为主。患者银屑病区严重程度指数平均得分为26.19±10.8分,92%的患者病情严重,影响生活质量。在病例中发现MS具有统计学意义。多发性硬化症患者中心性肥胖、高甘油三酯血症、空腹血糖水平升高和高血压的患病率较高。银屑病患者多发性硬化症的存在与严重程度无关。结论:银屑病患者应定期检查代谢综合征,以预防相关的死亡和有效的治疗。
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Psoriasis and its association with metabolic syndrome: A case–Control study at a tertiary care center in a semi-Urban region of South India
Background: Metabolic syndrome (MS) has been associated with skin diseases such as psoriasis. They share a common inflammatory pathway and therefore have an impact on each other. Objectives: To estimate the prevalence of MS and its individual components in psoriasis patients to that of the controls and to compare the characteristics in psoriasis patients with and without the MS. Materials and Methods: One hundred patients with a clinical diagnosis of chronic plaque psoriasis were evaluated for the prevalence of MS and compared with the age- and sex-matched controls. Results: The study population belongs to the semi-urban region with a low socioeconomic status. The psoriatic cases showed male preponderance, and the majority of the subjects belonged to 31–40 years of age group. The mean psoriasis area severity index score among cases was 26.19 ± 10.8, and 92% of cases were with severe disease affecting the quality of life. MS was found to be statistically significant in cases. The cases with MS had a higher prevalence of central obesity, hypertriglyceridemia, elevated fasting blood glucose levels, and hypertension. The presence of MS in psoriasis patients was statistically independent of the severity. Conclusions: Psoriasis patients should be periodically evaluated for metabolic syndrome to prevent the associated mortalities and for their effective management.
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