Anti-inflammatory activities of a sulfated polysaccharide isolated from the brown seaweed Padina boergesenii (Phaeophyceae, Dictyotaceae)

DOI: 10.21608/svu.2022.105385.1158 Received: November 16, 2021 Accepted: March 20, 2022 Published: March 30, 2022 *Corresponding Author: Ereen Kondos Naeem E-mail: ereenkondos@yahoo.com Citation: Kondos et al., Anti-inflammatory activities of a sulfated polysaccharide isolated from the brown seaweed Padina boergesenii (Phaeophyceae, Dictyotaceae) SVU-IJVS 2022, 5(1): 83-101. Copyright: © Kondos et al. This is an open access article distributed under the terms of the creative common attribution license, which permits unrestricted use, distribution and reproduction in any medium provided the original author and source are created. Competing interest: The authors have declared that no competing interest exists. Abstract Brown algae (BA) have recently gained high interest as a beneficial source of pharmacological numerous invaluable active constituents. Subsequently, water-soluble polysaccharides of BA attracted the attention of researchers worldwide due to their anticancer and antioxidant activities. This study was carried out to evaluate the anti-inflammatory activity of polysaccharides (PLS) extract of Padina boergesenii brown algae. Xylene produced-ear inflammation and carrageenan produced-paw edema models were used in this study. The PLS doses of 75, 125, 250, 500, 750, 1000 mg/kg were tested. Our obtained data revealed that PLS inhibited the inflammatory reactions of both models in a dose-dependent manner. Interestingly, the anti-inflammatory effect of PLS is associated with lowering of nitric oxide and MDA free radicals and pro-inflammatory cytokines: IL1β, IL-6, and TNF-α level. This data highlights the therapeutic significance of isolated PLS. As this polysaccharide possesses high anti-inflammatory activity in comparison to the anti-inflammatory drug diclofenac, therefore this natural compound could be recommended as an effective remedy for inflammation.