抗分泌药物在儿童急性水样腹泻治疗中的作用:一项随机对照试验

Reham Sayed, H. El-Masry, Ismail El-Razek Kasem
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引用次数: 0

摘要

背景与目的以往的研究表明,消旋卡多曲治疗儿童急性腹泻更安全有效。本研究旨在评价消旋卡多曲作为口服补液的增强剂在治疗5岁以下儿童急性水样腹泻中的作用。患者和方法本随机临床试验纳入50例入院前24 h内出现≥3次腹泻便的急性水样腹泻,持续时间小于等于5天的儿童,无轻至中度脱水。我们的研究已在clinicaltrials.gov注册(NCT05216822)。结果本研究的主要发现是消旋卡多曲能显著缩短腹泻发作时间和住院时间。这项研究表明,消旋卡多曲显示改善大便的稠度,从而保护患者免受水分流失和脱水。结论消旋卡多曲是一种有效的补液药,其止泻作用是通过抑制肠脑啡肽酶来实现的。它能有效减少排便量和次数。
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Role of antisecretory drug in treatment of children with acute watery diarrhea: A Randomized Controlled Trial
Background and aim Previous studies have shown that Racecadotril is safer and more effective in treating children with acute diarrhea. This study aimed to evaluate the effect of Racecadotril as a booster to oral rehydration solution in the management of acute watery diarrhea among children aged 5 years or less. Patients and methods This random clinical trial included 50 children with acute watery diarrhea for less than or equal to 5 days with a frequency of more than or equal to three diarrheic stools in the past 24 h before admission to the hospital, with no mild-to-moderate dehydration. Our study is registered to clinicaltrials.gov (NCT05216822). Results The main findings of this study were that Racecadotril reduced the duration of the diarrheal episodes and the duration of hospitalization significantly. This study revealed that Racecadotril showed an improvement in the consistency of stool, which protects the patient from fluid loss and dehydration. Conclusion Racecadotril is an effective booster-rehydration drug that carries out its antidiarrheal effect by inhibiting intestinal enkephalinase. It is efficient in reducing the volume and frequency of stool output.
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审稿时长
34 weeks
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