非肌肉浸润性膀胱癌肿瘤深度、宽度与淋巴血管浸润的关系

IF 0.8 Q4 UROLOGY & NEPHROLOGY Urological Science Pub Date : 2022-04-01 DOI:10.4103/uros.uros_112_21
Kevin Glorius Tampubolon, S. Pramod, Ferry Safriadi, M. Fitriana, B. Hernowo
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引用次数: 0

摘要

目的:约75%的膀胱癌被归类为非肌肉浸润性癌症(NMIBC)。NMIBC的高复发率和进展率最常见于侵犯固有层(LP)的肿瘤,当其扩展到具有异质性复发和进展的LP时,被归类为pT1期。本研究旨在将NMIBC中肿瘤深度和宽度的测量与淋巴血管侵袭(LVI)相关联。材料和方法:在印度尼西亚的一家三级医院进行了一项为期5年的回顾性分析研究(2015-2019)。我们根据组织病理学报告对64例pT1膀胱癌症患者的肿瘤深度和宽度进行了重新评估和分析,并分析了肿瘤与LVI的相关性。通过以LP作为初始标记点测量移行性尿路上皮,直至LP中的肿瘤边缘,并通过组织病理学检查测量LP中一个肿瘤病灶的最大宽度以及LVI的存在来重新评估深度。使用Mann-Whitney检验对数据进行分析。结果:受试者为64例pT1膀胱癌症患者。肿瘤pT1的平均侵袭深度为2.03±0.918mm。非LVI组的平均肿瘤侵袭深度为1.72±0.721mm,而LVI组为2.21±0.980mm。肿瘤侵袭深度是LVI的一个重要因素,而肿瘤最大直径则不是。结论:肿瘤浸润深度与LVI显著相关。pT1肿瘤浸润深度测量可作为肿瘤复发和进展的预测变量。
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Correlations of tumor depth and width with lymphovascular invasion in non-muscle invasive bladder cancer
Purpose: Around 75% of all bladder cancers are classified into nonmuscle invasive bladder cancer (NMIBC). The NMIBC's high recurrence and progressivity rate are most commonly found in tumors invading the lamina propria (LP), classified as staged pT1 when it extended to the LP with a heterogeneous recurrence and progression. This study aimed to correlate the measurement of tumor depth and width to lymphovascular invasion (LVI) in NMIBC. Materials and Methods: A 5-year retrospective analytical study (2015–2019) was conducted in a tertiary hospital in Indonesia. We reassessed and analyzed the tumor depth and width of 64 patients with pT1 bladder cancer based on histopathological reports and analyzed the correlation of tumors and LVI. The depth was reassessed by measuring the transitional urothelium with the LP as an initial marking point, up to the tumor's edge in the LP, and tumor's width by measuring the largest width of one tumor focus in the LP, along with the presence of LVI by histopathological exams. Data were analyzed using the Mann − Whitney test. Results: The participants were 64 patients with pT1 bladder cancer. The mean tumor pT1 invasion depth was 2.03 ± 0.918 mm. The non-LVI group's mean tumor invasion depth was 1.72 ± 0.721 mm, whereas the LVI group was 2.21 ± 0.980 mm. The tumor invasion depth was a significant factor for LVI, whereas the tumor maximum diameter was not. Conclusion: The tumor invasion's depth was significantly associated with the LVI. The pT1 tumor invasion depth measurement might serve as a predictive variable of tumor recurrence and progressivity.
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来源期刊
Urological Science
Urological Science UROLOGY & NEPHROLOGY-
CiteScore
1.20
自引率
0.00%
发文量
26
审稿时长
6 weeks
期刊最新文献
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