口服对乙酰氨基酚与布洛芬对儿童髁上骨折的镇痛效果比较:一项三盲随机临床试验

IF 1.3 Q3 PEDIATRICS International Journal of Pediatrics Pub Date : 2021-09-11 DOI:10.22038/IJP.2021.58555.4576
Morteza Talebi Deluee, Somaye Bagherian, B. Kakhki, A. Mousavian, H. Miri, E. Moradi
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引用次数: 0

摘要

简介:髁上骨折是常见的儿童,平均年龄为5-8岁。特别重要的是要注意这些孩子的疼痛控制,因为他们有很多疼痛。本研究旨在比较口服布洛芬与对乙酰氨基酚对接受非手术治疗的儿童髁上骨折的镇痛效果。材料与方法:本临床试验采用三盲法,治疗Emam Reza和Hosheminejad医院急诊科的儿童髁上骨折。研究人员在服用药物后2、4和12小时通过VAS(视觉模拟量表)标准评估儿童的疼痛,并向其父母解释。结果:在本研究中,研究了64名平均年龄为5.7±1.7岁的儿童。对对乙酰氨基酚组的31名儿童和布洛芬组的33名儿童进行了评估。两组在给药12小时内的平均疼痛评分下降没有差异(P=0.710)。给药12个小时后,分别有5名和7名儿童在服用对乙酰氨基酚和布洛芬后无痛,两组之间没有差异。结论:布洛芬和对乙酰氨基酚给药后12小时内,儿童镇痛效果相似,两种药物在镇痛和副作用方面没有显著差异,两种药对儿童疼痛控制安全有效。
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Comparison the analgesic effect of oral acetaminophen vs ibuprofen in children with supracondylar fractures: A Triple-blind Randomized Clinical Trial
Introduction: A supracondylar fracture are common in children with the average age of is 5-8 years. It is especially important to pay attention to pain control in these children because of lots of pain. This study was design to compare the analgesic effect of oral ibuprofen vs acetaminophen in children with supracondylar fractures who undergoing non-surgical treatment.Material & Methods: This triple-blind clinical trial was conducted on children with supracondylar fracture referred to the Emergency Department of Emam Reza and Hosheminejad Hospital. Children’s pain were assessed 2, 4 and 12 hours after taking the drug by VAS (Visual Analog Scale) criteria, which was explained by researcher to their parents. Results: In this study, 64 children with a mean age of 5.7±1.7 years were studied. 31 children in the acetaminophen group and 33 children in the ibuprofen group were evaluated. The mean pain score reduction within 12 hours of drug administration showed no difference between the two groups (P = 0.710). After 12 hours of drug administration, 5 and 7 children being painless in the acetaminophen and ibuprofen, respectively, with no difference between the two groups.Conclusion: During the 12 hours after ibuprofen and acetaminophen, children had similar analgesia and there was no significant difference between the two drugs in terms of pain relief and side effects, and both drugs are safe and effective for pain-control in children.
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来源期刊
CiteScore
3.90
自引率
0.00%
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0
审稿时长
4 weeks
期刊介绍: International Journal of Pediatrics is a peer-reviewed, open access journal that publishes original researcharticles, review articles, and clinical studies in all areas of pediatric research. The journal accepts submissions presented as an original article, short communication, case report, review article, systematic review, or letter to the editor.
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