用于HFRS疫苗开发的灭活剂的比较特性

Q4 Medicine Epidemiologiya i Vaktsinoprofilaktika Pub Date : 2018-09-19 DOI:10.31631/2073-3046-2018-17-4-26-29

C. C. Kurashova, A. Ishmukhametov, M. Egorova, M. Balovneva, T. Dzagurova, E. Tkachenko

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引用次数: 2

摘要

介绍了紫外线（UV）、β-丙内酯（BPL）和福尔马林灭活Puumala病毒的各种方法的结果。在BALB/c小鼠的实验中，使用这些病毒灭活方法获得的疫苗制剂的免疫原性没有显著差异。紫外线和BPL相对于甲醛的主要优点是病毒灭活时间短。

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Comparative Characteristics of Inactivation Agents for HFRS Vaccine Development

The results of various methods of Puumala virus inactivation, including ultraviolet rays (UV), β -propiolactone (BPL) and formalin are presented. Immunogenicity of vaccine preparations obtained using these virus inactivation methods did not differ significantly in the experiments on BALB/c mice. Essential advantage of UV and BPL in relation to formaldehyde is the short time of virus inactivation.

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