Elevated Systemic Immune – Inflammation Index for Predictor of Ulcerative Colitis: A Systematic Review and Meta-analysis

Introduction: The Systemic Immune-inflammation Index (SII) is a simple, non-invasive, and low-cost parameter that has been studied to predict ulcerative colitis (UC). However, the result remains inconclusive. Therefore, this study aimed to confirm the utilization of SII in UC. Methods: A systematic search was conducted. The inclusion criteria were articles that investigated the relationship between SII and UC and reported a specific cut-off value, specific sensitivity, specificity, and area under the curve (AUC). The odds ratio (OR) and mean difference (MD) using a 95 % confidence interval (CI) were used.