{"title":"中枢增敏对住院老年患者术后神经认知功能障碍的影响：一项前瞻性队列临床试验","authors":"Lili Yu, Dongliang Yang, Qi Zhou, Chunping Yin, Qi Zhang, Wei Li, Jiaxu Yu, Qiujun Wang","doi":"10.1080/0361073X.2023.2182093","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate whether central sensitization (CS) in elderly patients was a predictive risk factor for postoperative neurocognitive dysfunction (PNCD).</p><p><strong>Methods: </strong>One hundred and thirty-three aged patients undergoing total knee arthroplasty (TKA) who received femoral nerve block and general anesthesia were recruited in this research and prospectively assigned into two groups according to the Central Sensitization Inventory (CSI) score: group C (<i>n</i> = 106, CSI score less than 40) and group CS (<i>n</i> = 27, CSI score higher than 40). Scores of Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), Confusion Assessment Method (CAM), Numerical Rating Scale (NRS) and Quality of recovery-40 (QoR-40) questionnaires were assessed. Basic information and clinical records of all participants were also collected.</p><p><strong>Results: </strong>PNCD occurred in 24 (22.6%) of patients in group C and 16 (59.3%) in group CS (<i>p</i> < .05). Multivariate logistic regression analysis revealed that patients with CSI score ≥40 before surgery exhibited higher risk of PNCD after adjustment for other risk factors (<i>p</i> < .05). Compared to group C, the pre- and post-operative NRS scores, pain duration, the WOMAC score, and propofol consumptions for anesthesia induction were significantly increased in group CS (<i>p</i> < .05).</p><p><strong>Conclusion: </strong>Hospitalized elderly patients with clinical symptoms of CS scores may have increased risk of PNCD following TKA.</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Effect of Central Sensitization on Postoperative Neurocognitive Dysfunction in Hospitalized Elderly Patients: A Prospective Cohort Clinical Trial.\",\"authors\":\"Lili Yu, Dongliang Yang, Qi Zhou, Chunping Yin, Qi Zhang, Wei Li, Jiaxu Yu, Qiujun Wang\",\"doi\":\"10.1080/0361073X.2023.2182093\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To investigate whether central sensitization (CS) in elderly patients was a predictive risk factor for postoperative neurocognitive dysfunction (PNCD).</p><p><strong>Methods: </strong>One hundred and thirty-three aged patients undergoing total knee arthroplasty (TKA) who received femoral nerve block and general anesthesia were recruited in this research and prospectively assigned into two groups according to the Central Sensitization Inventory (CSI) score: group C (<i>n</i> = 106, CSI score less than 40) and group CS (<i>n</i> = 27, CSI score higher than 40). Scores of Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), Confusion Assessment Method (CAM), Numerical Rating Scale (NRS) and Quality of recovery-40 (QoR-40) questionnaires were assessed. Basic information and clinical records of all participants were also collected.</p><p><strong>Results: </strong>PNCD occurred in 24 (22.6%) of patients in group C and 16 (59.3%) in group CS (<i>p</i> < .05). Multivariate logistic regression analysis revealed that patients with CSI score ≥40 before surgery exhibited higher risk of PNCD after adjustment for other risk factors (<i>p</i> < .05). Compared to group C, the pre- and post-operative NRS scores, pain duration, the WOMAC score, and propofol consumptions for anesthesia induction were significantly increased in group CS (<i>p</i> < .05).</p><p><strong>Conclusion: </strong>Hospitalized elderly patients with clinical symptoms of CS scores may have increased risk of PNCD following TKA.</p>\",\"PeriodicalId\":12240,\"journal\":{\"name\":\"Experimental Aging Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Experimental Aging Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/0361073X.2023.2182093\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/2/22 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental Aging Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/0361073X.2023.2182093","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/2/22 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
The Effect of Central Sensitization on Postoperative Neurocognitive Dysfunction in Hospitalized Elderly Patients: A Prospective Cohort Clinical Trial.
Objective: To investigate whether central sensitization (CS) in elderly patients was a predictive risk factor for postoperative neurocognitive dysfunction (PNCD).
Methods: One hundred and thirty-three aged patients undergoing total knee arthroplasty (TKA) who received femoral nerve block and general anesthesia were recruited in this research and prospectively assigned into two groups according to the Central Sensitization Inventory (CSI) score: group C (n = 106, CSI score less than 40) and group CS (n = 27, CSI score higher than 40). Scores of Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), Confusion Assessment Method (CAM), Numerical Rating Scale (NRS) and Quality of recovery-40 (QoR-40) questionnaires were assessed. Basic information and clinical records of all participants were also collected.
Results: PNCD occurred in 24 (22.6%) of patients in group C and 16 (59.3%) in group CS (p < .05). Multivariate logistic regression analysis revealed that patients with CSI score ≥40 before surgery exhibited higher risk of PNCD after adjustment for other risk factors (p < .05). Compared to group C, the pre- and post-operative NRS scores, pain duration, the WOMAC score, and propofol consumptions for anesthesia induction were significantly increased in group CS (p < .05).
Conclusion: Hospitalized elderly patients with clinical symptoms of CS scores may have increased risk of PNCD following TKA.
期刊介绍：
Experimental Aging Research is a life span developmental and aging journal dealing with research on the aging process from a psychological and psychobiological perspective. It meets the need for a scholarly journal with refereed scientific papers dealing with age differences and age changes at any point in the adult life span. Areas of major focus include experimental psychology, neuropsychology, psychobiology, work research, ergonomics, and behavioral medicine. Original research, book reviews, monographs, and papers covering special topics are published.
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