Investigation of hemotoxicologic potential of an ayurvedic preparation Kutajarista used in Sprue syndrome after chronic administration to male Sprague-Dawley rats

The ayurvedic medicinal system is the world’s most primitive medical systems which were originated in India. For the treatment of Sprue syndrome, a very well-known ayurvedic preparation named Kutajarista (KTJ) is used in the south Asian region. This study aimed to detect the impact of chronic administration of KTJ on hematological parameters. The experimental animals were subdivided into two groups. A high dose (50 mL/kg) of body weight was given to the first group for 42 days and the second group which was considered as the control group was treated with normal water for the same period. There was a remarkable reduction [10.37%, p=0.092] in the total numbers of red blood cells (RBC). A prominent decrease [10.75%. p=0.097] is also observed in the hemoglobin content of the blood. There was a noticeable [11.05%, p=0.077] decrease in the hematocrit level of the blood and a very high [64.35%, p=0.19] increase in the number of white blood cell (WBC) count of the male Sprague-Dawley rat. A remarkably high increase was observed in the absolute count of Neutrophils (220.161%, p=0.12), Eosinophils (368.75%, p=0.11), Lymphocytes [11.29%, p=0.06], and Monocyte [142.781%, p=0.13] count. Also a prominent [↑ 14.15%, p=0.42] increase in the number of platelet counts was observed. Rat cutaneous tail bleeding time and whole blood clotting time shortening were also observed and the result is statistically prominent. As the result shows a significant change in different hematological parameter it can be summarized that KTJ have potential hemotoxicity at a higher dose. Further study is required at a lower dose. Key words: Ayurvedic, Kutajarista, hemotoxicity, red blood cells (RBC), white blood cells (WBC).