病理性Tau蛋白激活小胶质细胞在认知障碍中的作用

Dengyang Han, N. Yang
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引用次数: 1

摘要

Tau过度磷酸化形成的神经纤维缠结(NFT)被认为是认知障碍的重要原因之一。高磷酸化的Tau以多种形式存在于中枢神经系统中,对神经元产生毒性作用,并激活小胶质细胞诱导免疫反应。本文旨在探讨病理性Tau的神经毒性,并阐明小胶质细胞在其与认知障碍的关系中的作用。通过调节小胶质细胞的分化方向和控制分化后的小胶质细胞分泌因子,我们可以干预病理性Tau蛋白引起的认知障碍。关键词:陶;小胶质细胞;神经退行性疾病;认知障碍
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The role of microglia activation by pathological Tau protein in cognitive impairment
Neurofibrillary tangle (NFT) formed by hyperphosphorylated Tau is considered to be one of the important reasons of cognitive impairment. Hyperphosphorylated Tau exists in many forms in the central nervous system, producing toxic effects on neurons and activating microglia to induce immune response. This paper aims to explore the neurotoxicity of pathological Tau and to elucidate the role of microglia in its association with cognitive impairment. By regulating the differentiation direction of microglia and controlling the secretory factors of differentiated microglia, we can intervene in the cognitive impairment caused by pathological Tau protein. Key words: Tau; Microglia; Neurodegenerative disease; Cognitive impairment
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