Thermodynamics and micellization behavior of choline based ionic liquids in presence of drug Cetrizine dihydrochloride

Abstract Ionic liquids (IL) have attained immense interest as substitutes for conventionally available surfactants because of their exceptionally favorable physicochemical properties. Most synthesized IL surfactants are not environmentally benign, and even utilizing high concentration, they form unstable micelles. In this regard, we have synthesized biocompatible and halogen free choline based ionic liquids by varying anions (choline oleate and cholinium bis(2-ethylhexyl) sulfosuccinate) and further investigated their micellization behavior in presence of the drug Cetrizine dihydrochloride. Characterizations of these synthesized ionic liquids were performed utilizing 1HNMR spectroscopy. The thermodynamic investigation and determination of various surface-active parameters were based on tensiometry and conductometric titrations. The CMC value of choline oleate ([CHO][Ole]) was found to be lower than that of [Cho][AOT] and thus it has a better surface activity. The thermodynamic parameters (ΔGm0${{\Delta}G}_{m}^{0}$, ΔHm0${{\Delta}H}_{m}^{0}$, and ΔSm0${{\Delta}S}_{m}^{0}$) signifies spontaneous, stable, exothermic and entropy driven nature of micellization process. The various interfacial and surface parameters have been evaluated employing tensiometry. These environmentally friendly ionic liquids have been utilized as substitute for conventional surfactants including their applications in biology and pharmaceutical industries.