Structure-antimicrobial activity relationships of monoketone curcuminoids

Dental caries constitutes a major public health concern worldwide. This pathology is caused by acidogenic and aciduric bacteria, which produce a structurally and functionally organized biofilm (dental plaque)on the tooth surface.1 Streptococcus mutansis one of the most important colony-forming bacteria present in the bucal microbiota, stands out due its ability of producing substances that favor adhesion and the accumulation of other microorganisms, forming a resistant extracellular matrixthat can destroy dental hard tissue.2 Brushing and flossing the teeth to remove dental plaque, as well as conducting periodic dental cleaning or prophylaxis are the most efficient ways to prevent caries. However, most people fail to maintain an efficient biofilm control through mechanical removal only, which has increased the use of oral products containing antimicrobial agents to diminish biofilm formation on the tooth surface.3 Although chlorhexidine is currently the most effective anti plaque agent, its use have been recommended by dentists only for short periods due to reversible local side effects.4