Influence of endovascular treatment on the vascular endothelium in patients with peripheral arterial disease: a systematic review

Peripheral arterial disease (PAD) is a major public health problem. Endothelial dysfunction represents an important mechanism in the development and progression of atherosclerosis, in part attributable to inflammation, platelet and smooth muscle activation, and arterial stiffening. The aim of this study was to explore the impact of lower limb revascularization on endothelial function in patients with PAD. We performed a comprehensive search of the academic literature using the PubMed and Embase databases to screen suitable records. Following the application of our search strategies, a total of eight studies were included in this review. Despite the limited available evidence, the dearth of academic literature suggests that revascularization has a positive effect on endothelial functioning. The effects of endovascular revascularization on endothelial functioning in patients with PAD are subject to further research