用于化学-光热协同癌症治疗的pH/温度响应纳米复合材料

Q1 Engineering Smart Materials in Medicine Pub Date : 2023-01-01 DOI:10.1016/j.smaim.2022.09.004
Rawand A. Mustafa , Meixin Ran , Yonghui Wang , Jiaqi Yan , Yu Zhang , Jessica M. Rosenholm , Hongbo Zhang
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引用次数: 5

摘要

为了优化协同治疗乳腺癌,制备了一种具有ph -温度响应和化学-光热联合治疗的纳米复合材料。本文中,金纳米棒(aunr)被[聚[(n -异丙基丙烯酰胺)-co-(甲基丙烯酸)](p(NIPAM-co-MAA))修饰的介孔二氧化硅(MS)包裹,用于递送阿霉素(DOX) (AuNR@DOX-MS@p(NIPAM-co-MAA))。在近红外辐射下,AuNR核心通过产生热量诱导热疗。同时,聚合物层在高温/低pH下坍塌,从而触发肿瘤部位的MS壳释放DOX。使用该纳米复合材料,DOX在生理pH/温度下几乎没有过早释放,而在较高温度/较低pH值下则有有效释放。此外,体外研究表明,纳米复合材料对MDA-MB-231乳腺癌细胞具有可观的摄取效率,在激光照射下对MDA-MB-231细胞增殖的抑制作用显著增强。体内实验进一步验证了制备的纳米复合材料在肿瘤部位的高效蓄积和静脉注射后对小鼠肿瘤生长的良好抑制能力,同时对机体主要器官具有良好的生物安全性。因此,合成的纳米复合材料可能是一种潜在的纳米载体,具有化疗-光热协同治疗的能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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A pH/temperature responsive nanocomposite for chemo-photothermal synergistic cancer therapy

To optimize synergistic breast cancer treatment, a nanocomposite was fabricated with pH-temperature responsive and chemo-photothermal combination therapy. Herein, gold nanorods (AuNRs) are coated with [poly[(N-isopropylacrylamide)-co-(methacrylic acid)] (p(NIPAM-co-MAA)) modified mesoporous silica (MS) for Doxorubicin (DOX) delivery (AuNR@DOX-MS@p(NIPAM-co-MAA)). Upon NIR radiation, the AuNR core induced hyperthermia via generating heat. Simultaneously, the polymer layer collapsed in response to high temperature/low pH, which allowed the triggering of DOX release from the MS shell at the tumor site. With this nanocomposite, nearly zero premature release of DOX at physiological pH/temperature was detected, while effective DOX release was reported at higher temperature/lower pH values. In addition, in vitro studies demonstrated that the nanocomposite has a substantial uptake efficiency of MDA-MB-231 breast cancer cells, with a significant increase in suppressing MDA-MB-231 ​cell proliferation in response to laser irradiation. The in vivo experiments further verified the high efficiency of the fabricated nanocomposite in accumulating at the tumor site and the good capability in suppressing tumor growth in the mice upon intravenous injection, while exhibiting good biosafety in relation to major organs in the body. Thus, the synthesized nanocomposite could be a potential nanocarrier for breast cancer treatment with synergistic chemo-photothermal therapeutic capability.

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来源期刊
Smart Materials in Medicine
Smart Materials in Medicine Engineering-Biomedical Engineering
CiteScore
14.00
自引率
0.00%
发文量
41
审稿时长
48 days
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