纳武单抗联合伊匹单抗致贝克囊肿破裂1例

IF 1.1 Q4 ALLERGY Journal of Cutaneous Immunology and Allergy Pub Date : 2023-03-09 DOI:10.1002/cia2.12290

Marie Kubo MD, Tomomitsu Miyagaki MD, PhD, Hiroyuki Ohashi MD, Arisa Kishi MD, Kaoru Miyano MD, Tatsuro Okano MD, PhD, Mayuko Muto MD, Sora Takeuchi MD, PhD, Mitsuru Imamura MD, PhD, Takafumi Kadono MD, PhD

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摘要

新出现的证据表明，免疫检查点抑制剂（ICIs）通过增强抗肿瘤免疫反应，对各种恶性肿瘤具有巨大疗效。相反，ICIs可引起免疫相关不良反应（irAE），影响各种器官系统。在这里，我们报告了罕见的由ICIs引起的贝克囊肿破裂的病例。一位50岁的日本妇女转诊到我科，有3个月外阴肿大结节病史。她没有肌肉骨骼疾病史。临床检查显示，右侧外阴有一个12×16毫米大小的黑色结节（图1A），同侧腹股沟淋巴结肿大。肿瘤被切除，边缘为10mm，并进行前哨淋巴结活检（SLNB）。切除标本显示真皮中有大量圆形至椭圆形的黑色素肿瘤细胞浸润（图1B）。肿瘤厚度为2.9mm，SLNB为阴性。发现正电子发射断层扫描计算机断层扫描（CT）

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A case of ruptured Baker's cyst induced by nivolumab and ipilimumab

Here, we presented the rare case of ruptured Baker's cyst induced by immune checkpoint inhibitors (ICIs). The history of more than one immune-related adverse event (irAE) like our case was reported to be associated with a more persistent course of arthritis. Mild persistent inflammation without subjective symptoms might exist after first ICI therapy followed by ruptured Baker's cyst. It is important to pay attention to potential musculoskeletal irAEs in ICI-treated patients with multiple irAEs.

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