阿片类药物依赖患者肝脂肪变性的病理形态发生

L. Pinsky, N. Ovcharenko, M. Khaitovych, G. Solovyova, A. V. Koveshnikov, Soumavo Mukherjee
{"title":"阿片类药物依赖患者肝脂肪变性的病理形态发生","authors":"L. Pinsky, N. Ovcharenko, M. Khaitovych, G. Solovyova, A. V. Koveshnikov, Soumavo Mukherjee","doi":"10.25298/2616-5546-2021-5-1-44-49","DOIUrl":null,"url":null,"abstract":"Background. One of the significant factors in the progression of fibrotic changes in the liver is hepatocyte steatosis, that persists in drug addicted patients even after the elimination of the hepatitis C virus and cessation of drug use. Analysis of the pathomorphogenesis of hepatic steatosis in opioid dependence (OZ) will make it possible to assess the factors that affect ultrastructural changes in hepatocytes and the processes of lipid granule (LH) degradation. Objective. Assessment of ultrastructural changes in LH in the liver tissue of patients with OZ. Material and methods. Histological preparations of liver tissue from 20 patients with OZ aged 21 to 40 years (18 men and 2 women) with different duration of OZ and opioid tolerance. Results. There was established the following dependence of ultrastructural changes in the liver in patients with different duration of OZ and opioid tolerance. The most pronounced changes were noted in the group of patients with prolonged (more than 6 years) opioid intoxication and high tolerance to opioids in the liver tissue, in whom, along with severe steatosis, there were more significant violations of the mechanisms of LH degradation, destruction of cristae in mitochondria, a decrease in the number of lipophagosomes and PH with signs of superficial degradation than in the group of patients with OZ duration up to 6 years, as well as with moderate and high opioid tolerance. Conclusions. Ultrastructural changes in hepatocytes in the form of progression of steatosis in the centrilobular and periportal zones, a decrease in the activity of LH degradation, gross morphological changes in mitochondria, a decrease in the activity of surface LH degradation depend on the activity and duration of opioid dependence and are more pronounced with long-term (more than 6 years) highly progressive opioid dependence.","PeriodicalId":34878,"journal":{"name":"Gepatologiia i gastroenterologiia","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"PATHOMORPHOGENESIS OF LIVER STEATOSIS IN PATIENTS WITH OPIOID DEPENDENCE\",\"authors\":\"L. Pinsky, N. Ovcharenko, M. Khaitovych, G. Solovyova, A. V. Koveshnikov, Soumavo Mukherjee\",\"doi\":\"10.25298/2616-5546-2021-5-1-44-49\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background. One of the significant factors in the progression of fibrotic changes in the liver is hepatocyte steatosis, that persists in drug addicted patients even after the elimination of the hepatitis C virus and cessation of drug use. Analysis of the pathomorphogenesis of hepatic steatosis in opioid dependence (OZ) will make it possible to assess the factors that affect ultrastructural changes in hepatocytes and the processes of lipid granule (LH) degradation. Objective. Assessment of ultrastructural changes in LH in the liver tissue of patients with OZ. Material and methods. Histological preparations of liver tissue from 20 patients with OZ aged 21 to 40 years (18 men and 2 women) with different duration of OZ and opioid tolerance. Results. There was established the following dependence of ultrastructural changes in the liver in patients with different duration of OZ and opioid tolerance. The most pronounced changes were noted in the group of patients with prolonged (more than 6 years) opioid intoxication and high tolerance to opioids in the liver tissue, in whom, along with severe steatosis, there were more significant violations of the mechanisms of LH degradation, destruction of cristae in mitochondria, a decrease in the number of lipophagosomes and PH with signs of superficial degradation than in the group of patients with OZ duration up to 6 years, as well as with moderate and high opioid tolerance. Conclusions. Ultrastructural changes in hepatocytes in the form of progression of steatosis in the centrilobular and periportal zones, a decrease in the activity of LH degradation, gross morphological changes in mitochondria, a decrease in the activity of surface LH degradation depend on the activity and duration of opioid dependence and are more pronounced with long-term (more than 6 years) highly progressive opioid dependence.\",\"PeriodicalId\":34878,\"journal\":{\"name\":\"Gepatologiia i gastroenterologiia\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-06-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gepatologiia i gastroenterologiia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.25298/2616-5546-2021-5-1-44-49\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gepatologiia i gastroenterologiia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.25298/2616-5546-2021-5-1-44-49","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

背景肝细胞脂肪变性是肝脏纤维化变化进展的重要因素之一,即使在消除丙型肝炎病毒并停止药物使用后,这种变性仍会在药物成瘾患者中持续存在。分析阿片类药物依赖性肝脂肪变性的病理形态发生,将有可能评估影响肝细胞超微结构变化和脂质颗粒(LH)降解过程的因素。客观的OZ患者肝组织LH超微结构变化的评估。材料和方法。20名年龄在21至40岁的OZ患者(18名男性和2名女性)的肝组织的组织学制剂,这些患者具有不同的OZ持续时间和阿片类药物耐受性。后果在不同OZ持续时间和阿片类药物耐受性的患者中,肝脏超微结构变化存在以下依赖性。最明显的变化发生在肝组织中长期(超过6年)阿片类药物中毒和对阿片类物质高耐受的患者组中,在这些患者中,除了严重的脂肪变性外,LH降解、线粒体嵴破坏、,与OZ持续时间长达6年以及具有中度和高度阿片类药物耐受性的患者相比,具有表面降解迹象的脂吞噬体和PH的数量减少。结论。肝细胞的超微结构变化,表现为小叶中心区和门周区脂肪变性的进展,LH降解活性的降低,线粒体的大体形态变化,表面LH降解活性的降低取决于阿片类药物依赖的活性和持续时间,并且在长期(超过6年)高度进行性阿片类物质依赖时更为明显。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
PATHOMORPHOGENESIS OF LIVER STEATOSIS IN PATIENTS WITH OPIOID DEPENDENCE
Background. One of the significant factors in the progression of fibrotic changes in the liver is hepatocyte steatosis, that persists in drug addicted patients even after the elimination of the hepatitis C virus and cessation of drug use. Analysis of the pathomorphogenesis of hepatic steatosis in opioid dependence (OZ) will make it possible to assess the factors that affect ultrastructural changes in hepatocytes and the processes of lipid granule (LH) degradation. Objective. Assessment of ultrastructural changes in LH in the liver tissue of patients with OZ. Material and methods. Histological preparations of liver tissue from 20 patients with OZ aged 21 to 40 years (18 men and 2 women) with different duration of OZ and opioid tolerance. Results. There was established the following dependence of ultrastructural changes in the liver in patients with different duration of OZ and opioid tolerance. The most pronounced changes were noted in the group of patients with prolonged (more than 6 years) opioid intoxication and high tolerance to opioids in the liver tissue, in whom, along with severe steatosis, there were more significant violations of the mechanisms of LH degradation, destruction of cristae in mitochondria, a decrease in the number of lipophagosomes and PH with signs of superficial degradation than in the group of patients with OZ duration up to 6 years, as well as with moderate and high opioid tolerance. Conclusions. Ultrastructural changes in hepatocytes in the form of progression of steatosis in the centrilobular and periportal zones, a decrease in the activity of LH degradation, gross morphological changes in mitochondria, a decrease in the activity of surface LH degradation depend on the activity and duration of opioid dependence and are more pronounced with long-term (more than 6 years) highly progressive opioid dependence.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
15
审稿时长
2 weeks
期刊最新文献
CLASSIFICATIONS AND NON-SURGICAL TREATMENT OF ACUTE APPENDICITIS IN ADULTS: A COMPARATIVE LITERATURE REVIEW EFFECT OF MEROPENEM AND IMICENEM ON MICROBIOCENOSIS AND MORPHOLOGY OF THE SMALL INTESTINE IN RATS DEVELOPMENT OF A DOMESTIC ENZYME IMMUNE TEST SYSTEM FOR DETECTION OF ANTI-HEV IGM IN BLOOD SERUM ANATOMICAL AND EXPERIMENTAL REASONING OF LIVER RESECTION USING HYDRODISSECTION TECHNIQUE EFFECTIVENESS OF PORTAL BLOOD FLOW OCCLUSION TECHNIQUES WHEN PLANNING EXTENSIVE RESECTIONS IN PATIENTS WITH LIVER ECHINOCOCCOSIS
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1