不良反应的严重程度与接种mRNA-1273疫苗的卫生保健工作者的t细胞反应有关

Hanna Klingel, Maike Lauen, A. Krüttgen, M. Imöhl, M. Kleines
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引用次数: 3

摘要

关于mRNA-1273引发的T细胞反应的知识是有限的。我们调查了接种mRNA-1273疫苗的医护人员的不良反应和特异性T细胞释放干扰素γ的情况。在完全接种疫苗后7至13周,检测到低水平的特异性T细胞与抗体反应无关。第一次免疫后症状的严重程度和第二次免疫后的症状数量与T细胞反应有关。除了抗体反应外,评估T细胞反应也是至关重要的,因为即使是很少的特异性T细胞也可以增加对感染的保护。研究mRNA-1273诱导的炎症过程可能有助于提高反应原性和免疫原性。
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Severity of adverse reactions is associated with T-cell response in mRNA-1273 vaccinated health care workers
Knowledge about mRNA-1273 elicited T-cell response is limited. We investigated adverse reactions and interferon gamma release by specific T-cells among mRNA-1273 vaccinated health care workers. Seven to 13 weeks after complete vaccination low levels of specific T-cells were detected not correlating with antibody response. Severity of symptoms after first and number of symptoms after second immunization were associated with T-cell response. Assessment of T-cell response in addition to antibody response is crucial because even few specific T-cells could add to protection against infection. Investigation of mRNA-1273 induced inflammatory processes might help improve reactogenicity and immunogenicity.
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来源期刊
CiteScore
3.70
自引率
3.70%
发文量
29
审稿时长
8 weeks
期刊介绍: Clin Exp Vaccine Res, the official English journal of the Korean Vaccine Society, is an international, peer reviewed, and open-access journal. It covers all areas related to vaccines and vaccination. Clin Exp Vaccine Res publishes editorials, review articles, special articles, original articles, case reports, brief communications, and correspondences covering a wide range of clinical and experimental subjects including vaccines and vaccination for human and animals against infectious diseases caused by viruses, bacteria, parasites and tumor. The scope of the journal is to disseminate information that may contribute to elaborate vaccine development and vaccination strategies targeting infectious diseases and tumors in human and animals. Relevant topics range from experimental approaches to (pre)clinical trials for the vaccine research based on, but not limited to, basic laboratory, translational, and (pre)clinical investigations, epidemiology of infectious diseases and progression of all aspects in the health related issues. It is published printed and open accessed online issues (https://ecevr.org) two times per year in 31 January and 31 July. Clin Exp Vaccine Res is linked to many international databases and is made freely available to institutions and individuals worldwide
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