MTHFR C667T多态性与2型糖尿病患者糖尿病肾病易感性的最新荟萃分析

IF 0.5 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pteridines Pub Date : 2022-01-01 DOI:10.1515/pteridines-2022-0039
Xiao-dong Wang, Lejian Lan
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引用次数: 0

摘要

摘要背景大量研究表明,亚甲基四氢叶酸还原酶(MTHFR)C667T多态性与糖尿病肾病(DN)易感性之间存在相关性;尽管如此,个别研究报告的可用证据并不一致,因此我们进行了一项更新的荟萃分析,以评估MTHFR C667T变体与DN之间的关系。材料和方法从电子数据库PubMed、Embase、Scopus、中国生物医药和中国国家知识基础设施中检索2022年2月之前发表的相关研究。相关性的强度通过95%置信区间(CI)的比值比(OR)进行检验。结果在等位基因(OR=1.59,95%CI=1.39–1.82)、显性(OR=1.76,95%CI=1.47–2.11)和隐性(OR=1.85,95%CI=1.56–2.20)模型中,C677T和DN的多态性与DM对照组相比存在显著关系。此外,与健康对照组相比,在三个遗传比较模型中发现C677T与DN之间存在显著关系(等位基因:OR=1.81,95%CI=1.43–2.29;显性:OR=2.09,95%CI=1.54–2.85;隐性:OR=2.02,95%CI=1.51–2.70)。此外,按种族对数据进行分层,糖尿病持续时间和是否处于Hardy-Weinberg平衡显示,所有亚组对DN的易感性显著增加。结论目前的荟萃分析强调了C677T多态性与DN易感性之间强有力关联的结论性结果。
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MTHFR C667T polymorphism and diabetic nephropathy susceptibility in patients with type 2 diabetes mellitus: An updated meta-analysis
Abstract Background Numerous studies indicated that there exists a relationship between methylenetetrahydrofolate reductase (MTHFR) C667T polymorphism and diabetic nephropathy (DN) susceptibility; nonetheless, available proof reported from individual studies has not been consistent, so we performed an updated meta-analysis to evaluate the relationship between MTHFR C667T variant and DN. Materials and methods Relevant studies published before February 2022 were searched from the electronic databases PubMed, Embase, Scopus, Chinese Biology Medicine and the Chinese National Knowledge Infrastructure. The strength of the association was examined by odds ratio (OR) with 95% confidence interval (CI). Results The findings illustrated that there was a significant relationship between the polymorphism of C677T and DN compared with that to DM controls in allele (OR = 1.59, 95% CI = 1.39–1.82), dominant (OR = 1.76, 95% CI = 1.47–2.11) and recessive (OR = 1.85, 95% CI = 1.56–2.20) models in all populations. Moreover, as compared with the healthy controls, a significant relationship between C677T and DN was found in three genetic comparison models (allele: OR = 1.81, 95% CI = 1.43–2.29; dominant: OR = 2.09, 95% CI = 1.54–2.85; recessive: OR = 2.02, 95% CI = 1.51–2.70). Furthermore, stratifying data by race, diabetes duration and whether in Hardy–Weinberg equilibrium revealed substantially augmented vulnerability to DN in all subgroups. Conclusion The current meta-analysis highlighted conclusive results for the robust association between C677T polymorphisms and DN susceptibility.
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来源期刊
Pteridines
Pteridines 生物-生化与分子生物学
CiteScore
1.20
自引率
25.00%
发文量
6
审稿时长
>12 weeks
期刊介绍: Pteridines is an open acess international quarterly journal dealing with all aspects of pteridine research. Pteridines are heterocyclic fused ring compounds involved in a wide range of biological functions from the color on butterfly wings to cofactors in enzyme catalysis to essential vitamins. Of the pteridines, 5,6,7,8-tetrahydrobiopterin is the necessary cofactor of several aromatic amino acid monoxygenases, the nitric oxide synthases and glyceryl ether monoxygenase (GEMO). Neopterin plays an essential role in the immune system and is an important biomarker in laboratory medicine for diseases such as HIV, cardiovascular disease, malignant tumors, among others. Topics: -Neopterin, dihydroneopterin, monapterin- Biopterin, tetrahydrobiopterin- Folates, antifolates, riboflavin- Phenylalanine, tyrosine, phenylketonuria, serotonin, adrenalin, noradrenalin, L-DOPA, dopamine, related biogenic amines- Phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthases (iNOS), alkylglycerol monooxygenase (AGMO), dihydropterin reductase, sepiapterin reductase- Homocysteine, mediators of inflammation, redox systems, iron.
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