3M概念:从分子到小鼠再到人的生物医学转化成像

IF 1.2 Q3 MULTIDISCIPLINARY SCIENCES The EuroBiotech Journal Pub Date : 2021-07-01 DOI:10.2478/ebtj-2021-0024
D. Máthé, B. Kiss, B. Pályi, Z. Kis, László Forgách, N. Hegedűs, Z. Varga, K. Szigeti, K. Karlinger, M. Kellermayer
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引用次数: 0

摘要

摘要成像不断渗透到生物医学科学,从纳米级到床边。然而,将生物医学的层次结构与相关的成像方法联系起来仍然是一个挑战。在这里,我们提出了一个名为“3M”的概念,它可以在床边提出一个问题,跨越生物体的广泛层次组织,从分子水平,到小动物规模,再到全身人类功能成像。我们展示了一个从原子力显微镜延伸到临床前全身成像方法的纳米颗粒开发管道的例子,以突出3M概念的基本特征,该概念将多尺度分辨率和量化集成到一个单一的逻辑过程中。使用纳米级到人体临床全身的方法,我们介绍了普鲁士蓝纳米颗粒在各种成像模式中的成功开发、表征和应用,并将其扩展到同位素有效载荷量化和形状生物分布关系。将一个想法从床边转换到分子水平再转换回来,需要一套新的组合成像方法,这些方法相互连接成一个逻辑管道。所提出的整合分子到小鼠到人(3M)方法提供了一个有前景的、面向临床的工具包,有可能从尽可能小的人体体素中获得越来越多的相关信息。
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The 3M Concept: Biomedical Translational Imaging from Molecules to Mouse to Man
Abstract Imaging keeps pervading biomedical sciences from the nanoscale to the bedside. Connecting the hierarchical levels of biomedicine with relevant imaging approaches, however, remains a challenge. Here we present a concept, called “3M”, which can deliver a question, formulated at the bedside, across the wide-ranging hierarchical organization of the living organism, from the molecular level, through the small-animal scale, to whole-body human functional imaging. We present an example of nanoparticle development pipeline extending from atomic force microscopy to pre-clinical whole body imaging methods to highlight the essential features of the 3M concept, which integrates multi-scale resolution and quantification into a single logical process. Using the nanoscale to human clinical whole body approach, we present the successful development, characterisation and application of Prussian Blue nanoparticles for a variety of imaging modalities, extending it to isotope payload quantification and shape-biodistribution relationships. The translation of an idea from the bedside to the molecular level and back requires a set of novel combinatorial imaging methodologies interconnected into a logical pipeline. The proposed integrative molecules-to-mouse-to-man (3M) approach offers a promising, clinically oriented toolkit that lends the prospect of obtaining an ever-increasing amount of correlated information from as small a voxel of the human body as possible.
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来源期刊
The EuroBiotech Journal
The EuroBiotech Journal Agricultural and Biological Sciences-Food Science
CiteScore
3.60
自引率
0.00%
发文量
17
审稿时长
10 weeks
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