Yi Zhang, Xu Wang, Yiwen Yang, Ya-qin Wei, Li Sheng, Lu Yu
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Jiawei Sijunzi Soup Inhibits Inflammation and Oxidative Stress in the Rat Model of Diabetic Gastroparesis
Diabetic gastroparesis is a common complication of diabetes that may lead to poor nutrition, problems managing blood glucose, and a reduced quality of life. Jiawei Sijunzi soup has been shown to benefit patients with amyotrophic lateral sclerosis while causing no serious side effects. In this study, we investigated the possible effects of Jiawei Sijunzi soup on the progression of diabetic gastroparesis in a rat model induced by streptozotocin. The results show that Jiawei Sijunzi soup reduced inflammation and oxidative stress and improved the pathological features of gastric tissue in diabetic gastroparesis. The target of Jiawei Sijunzi soup in diabetic gastroparesis was analyzed based on network pharmacology and molecular docking techniques. The results show activation of the PI3K/AKT pathway by Jiawei Sijunzi soup in the rat model of diabetic gastroparesis.
期刊介绍：
Current Topics in Nutraceutical Research is an international, interdisciplinary broad-based peer reviewed scientific journal for critical evaluation of research on chemistry, biology and therapeutic applications of nutraceuticals and functional foods. The major goal of this journal is to provide peer reviewed unbiased scientific data to the decision makers in the nutraceutical and food industry to help make informed choices about development of new products.
To this end, the journal will publish two types of review articles. First, a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, a critical evaluation of current human experimental data to help market and deliver the product for medically proven use. This journal will also serve as a forum for nutritionists, internists, neurologists, psychiatrists, and all those interested in preventive medicine.
The common denominator of all of the topic to be covered by the journal must include nutraceuticals and/functional food. The following is an example of some specific areas that may be of interest to the journal. i) Role of vitamins, minerals, antioxidants and phytonutrients on cardiovascular health, cancer, diabetes, ocular health, mental health, men’s health, women’s health, infant nutrition, ii) Role of herbals on human health, iii) Dietary supplements and sleep, iv) Components of diet that may have beneficial effect on human health, v) regulation of apoptosis and cell viability, vi) Isolation and characterization of bioactive components from functional foods, vii) Nutritional genomics, and viii) Nutritional proteomics.
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