阿育吠陀配方Sramahara Mahaakaasaya的安全性和抗疲劳活性-临床前研究

Q4 Pharmacology, Toxicology and Pharmaceutics Toxicology International Pub Date : 2023-02-07 DOI:10.18311/ti/2022/v29i4/30296

Bidhan Mahajon, A. Ramamurthy, Rupashri Nath, M. Gautam, Neeladrisingha Das, P. Roy

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引用次数: 0

摘要

本文系统评价了Shramahara Mahaakashaaya (SM)抗疲劳活性的实验评价及其在运动医学中的适用性。研究SM颗粒水、醇、石油醚提取物(200mg/kg)抗焦虑作用的光暗模型试验、肌张力和肌肉平衡作用的旋转杆试验、抗疲劳活性的负重强迫游泳试验。SM颗粒的急性毒性研究也根据OECD 423进行了评估。SM颗粒在不同的实验模型中显示出明显的抗疲劳活性，且在2000mg/kg体重剂量下是安全的。本研究结果为将沙摩原Mahaakashaaya (SM)作为一种具有抗疲劳作用的替代药物，进一步纳入运动医学提供了重要依据。

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Safety and Anti-Fatigue Activity of Ayurvedic Formulation Sramahara Mahaakaasaya - A Pre-Clinical Study

An experimental evaluation of anti-fatigue activity of Shramahara Mahaakashaaya (SM) and its applicability in sports medicine has been systematically evaluated. Aqueous, ethanolic and petroleum ether extracts of SM granules (200mg/kg) were studies for light-dark model test for assessment anti-anxiety effect, rota-rod test for assessment of the effect on muscle tone and muscle balance, weight loaded forced swimming test for assessment of anti-fatigue activity. The acute toxicity study of SM granules has also been evaluated as per the OECD 423. SM granules showed significant anti-fatigue activity in different experimental models and found safe up to 2000mg/kg body weight dose. The results provide an important basis for considering Shramahara Mahaakashaaya (SM) as an alternative medicine having anti-fatigue effects which can be further included in the sports medicine.

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来源期刊

Toxicology International Environmental Science-Health, Toxicology and Mutagenesis

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： Toxicology International is a peer-reviewed International Research Journal published bi-annually by the Society of Toxicology, India. The Journal is concerned with various disciplines of Toxicology including man, animals, plants and environment and publishes research, review and general articles besides opinions, comments, news-highlights and letters to editor.