{"title":"长链非编码RNA HOTAIR在白血病中的研究进展","authors":"Chen Wang","doi":"10.3760/CMA.J.ISSN.1006-9801.2019.12.017","DOIUrl":null,"url":null,"abstract":"Long non-coding RNA (lncRNA) is a kind of regulatory RNA molecules with a length of more than 200nt, which can be involved in epigenetic modification of cells and gene expression by altering the chromatin status. HOTAIR is a kind of lncRNA, and some researches have found that HOTAIR may involved in the occurrence and development of leukemia, and it is obviously related to the diagnosis, treatment and prognosis of leukemia. This review summarizes the discovery, function, detection methods of HOTAIR and the latest research progress in leukemia, to provide new ideas for the diagnosis, individualized treatment and prognosis of leukemia. \n \n \nKey words: \nLeukemia; Long non-coding RNA; Diagnosis; HOTAIR; Prognosis","PeriodicalId":9505,"journal":{"name":"肿瘤研究与临床","volume":"31 1","pages":"858-861"},"PeriodicalIF":0.0000,"publicationDate":"2019-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Progress of long non-coding RNA HOTAIR in leukemia\",\"authors\":\"Chen Wang\",\"doi\":\"10.3760/CMA.J.ISSN.1006-9801.2019.12.017\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Long non-coding RNA (lncRNA) is a kind of regulatory RNA molecules with a length of more than 200nt, which can be involved in epigenetic modification of cells and gene expression by altering the chromatin status. HOTAIR is a kind of lncRNA, and some researches have found that HOTAIR may involved in the occurrence and development of leukemia, and it is obviously related to the diagnosis, treatment and prognosis of leukemia. This review summarizes the discovery, function, detection methods of HOTAIR and the latest research progress in leukemia, to provide new ideas for the diagnosis, individualized treatment and prognosis of leukemia. \\n \\n \\nKey words: \\nLeukemia; Long non-coding RNA; Diagnosis; HOTAIR; Prognosis\",\"PeriodicalId\":9505,\"journal\":{\"name\":\"肿瘤研究与临床\",\"volume\":\"31 1\",\"pages\":\"858-861\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-12-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"肿瘤研究与临床\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1006-9801.2019.12.017\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"肿瘤研究与临床","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1006-9801.2019.12.017","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Progress of long non-coding RNA HOTAIR in leukemia
Long non-coding RNA (lncRNA) is a kind of regulatory RNA molecules with a length of more than 200nt, which can be involved in epigenetic modification of cells and gene expression by altering the chromatin status. HOTAIR is a kind of lncRNA, and some researches have found that HOTAIR may involved in the occurrence and development of leukemia, and it is obviously related to the diagnosis, treatment and prognosis of leukemia. This review summarizes the discovery, function, detection methods of HOTAIR and the latest research progress in leukemia, to provide new ideas for the diagnosis, individualized treatment and prognosis of leukemia.
Key words:
Leukemia; Long non-coding RNA; Diagnosis; HOTAIR; Prognosis
期刊介绍：
"Cancer Research and Clinic" is a series of magazines of the Chinese Medical Association under the supervision of the National Health Commission and sponsored by the Chinese Medical Association.
It mainly reflects scientific research results and academic trends in the field of malignant tumors. The main columns include monographs, guidelines and consensus, standards and norms, treatises, short treatises, survey reports, reviews, clinical pathology (case) discussions, case reports, etc. The readers are middle- and senior-level medical staff engaged in basic research and clinical work on malignant tumors.
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