慢性阻塞性肺疾病炎症参数与硫醇/二硫化物系统抗氧化保护的相互作用

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL Russian Open Medical Journal Pub Date : 2022-12-20 DOI:10.15275/rusomj.2022.0411
T. Vitkina, E. Mineeva, K. Sidletskaya
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引用次数: 0

摘要

引言——考虑到这一过程中关键参与者的相互作用,慢性阻塞性肺病(COPD)发病率和患病率的增加为描述疾病进展机制提供了依据。本研究的目的是建立稳定型慢性阻塞性肺病(COPD)患者硫醇/二硫化物系统成分和适应性免疫单位的功能障碍参数。材料和方法——我们检查了中度(62名受试者)或重度(50名受试人)的稳定型COPD患者。对照组包括32名受试者。用ELISA法研究氧化应激的促氧化剂和抗氧化标志物。我们用流式细胞术(BD FACSCanto II,USA)测定了血浆中的细胞因子水平和表达IL-6R的T辅助细胞的数量。采用Terentiev的相关性指数对数据进行可视化。结果——不同严重程度COPD受试者抗氧化和细胞因子状态的变化表明,在适应性免疫单元不受控制的激活条件下,全身炎症的进展,而不仅仅是过氧化物平衡的改变和氧代谢产物的增加。结论:生物分子过氧化产物的积累、抗氧化系统的失衡以及炎症发病机制的改变可能导致支气管肺病理加重。
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Interaction Of Inflammatory Parameters And Thiol/Disulfide System Of Antioxidant Protection In Chronic Obstructive Pulmonary Disease
Introduction — Increased incidence and prevalence of chronic obstructive pulmonary disease (COPD) provides rationale for describing the disease progression mechanism, considering the interaction of key participants of this process. The objective of our study was to establish the dysfunction parameters of thiol/disulfide system components and adaptive immunity unit in patients with stable chronic obstructive pulmonary disease (COPD). Material and Methods — We examined patients with stable COPD of moderate (62 subjects) or severe (50 subjects) grades. The control group included 32 subjects. Prooxidant and antioxidant markers of oxidative stress were investigated with ELISA. We determined cytokine levels in blood plasma and the number of T helper cells expressing IL-6R with flow cytometry (BD FACSCanto II, USA). Correlation pleiads sensu Terentiev were employed to visualize the data. Results — Changes in both antioxidant and cytokine status of subjects with COPD of varying severity grades implied the progression of systemic inflammation in conditions of uncontrolled activation of adaptive immunity unit rather than just a shift in the peroxide balance and an increase in oxygen metabolites. Conclusion — Accumulation of biomolecule peroxidation products, imbalance in the prooxidant-antioxidant system, and a change in pathogenetic mechanism of inflammation could lead to an aggravated course of bronchopulmonary pathology.
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来源期刊
Russian Open Medical Journal
Russian Open Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
0.90
自引率
0.00%
发文量
39
期刊介绍: Russian Open Medical Journal (RusOMJ) (ISSN 2304-3415) is an international peer reviewed open access e-journal. The website is updated quarterly with the RusOMJ’s latest original research, clinical studies, case reports, reviews, news, and comment articles. This Journal devoted to all field of medicine. All the RusOMJ’s articles are published in full on www.romj.org with open access and no limits on word counts. Our mission is to lead the debate on health and to engage, inform, and stimulate doctors, researchers, and other health professionals in ways that will improve outcomes for patients. The RusOMJ team is based mainly in Saratov (Russia), although we also have editors elsewhere in Russian and in other countries.
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