肠道微生物群与癌症相关营养不良

Qinyue Wang, Dan Li, Jingtao Sun, Jiai Yan, Yingyu Wang, Ju Yang, Feng Zhang
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引用次数: 1

摘要

癌症相关营养不良(CAM)是癌症患者生存和生活质量的一大威胁。已经阐明了CAM发生和发展的几种机制。近几十年来,肠道微生物群紊乱在恶性肿瘤和营养不良中的作用越来越受到关注。然而,关于肠道微生物群与CAM之间相关性的研究仍处于初级阶段。这篇综述证明了由营养缺乏或过量诱导的肠道微生物群失调引起的CAM的触发因素,以及通过调节肠道微生物群来减轻CAM。还讨论了肠道微生物群在CAM恶化或改善中的潜在机制。肠道微生物群在CAM影响中的作用仍有待进一步研究。
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Gut microbiota and cancer-associated malnutrition
Cancer-associated malnutrition (CAM) is a great threat to the survive and life quality of patients with cancer. Several mechanisms have been elucidated in the occurrence and development of CAM. In recent decades, roles of the disordered gut microbiota in the malignant tumor and the malnutrition drew more and more attention. However, study on the correlation between gut microbiota with CAM still remains in its infancy. This review demonstrates the trigger for the CAM resulting from the dysbiosis of the gut microbiota induced by the nutrition deficiency or excess and the alleviation of CAM by the modulation of the gut microbiota. The underlying mechanisms of the gut microbiota in the aggravation or amelioration of CAM are also discussed. Further study is still warranted in the roles of the gut microbiota in the influence of CAM.
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