二甲双胍相关性乳酸中毒1例报告

IF 0.1 Q4 EMERGENCY MEDICINE Journal of Emergency Medicine Case Reports Pub Date : 2023-05-14 DOI:10.33706/jemcr.1294738
I. Akbas, Caner Akufuk, Muhammet Mustafa Yilmaz, Atilla Eren Kurt, Fatih Coşkun
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引用次数: 1

摘要

二甲双胍是一种双胍类口服抗糖尿病药物,用于肾功能正常的2型糖尿病患者。二甲双胍中毒并发乳酸的病例死亡率较高。在急诊科,在鉴别诊断使用二甲双胍并患有高阴离子间隙代谢性酸中毒(乳酸酸中毒)的患者时,应考虑二甲双胍中毒。早期诊断的最重要和有效的治疗方法是用血液透析或血液过滤方法纠正代谢性酸中毒,碳酸氢盐治疗,调整血糖水平。心血管系统支持治疗显著降低发病率/死亡率。在本病例报告中,我们介绍了一例因二甲双胍中毒引起的乳酸酸中毒患者的早期诊断和成功治疗。
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A Case Report of Metformin Related Lactic Acidosis
Metformin is an oral antidiabetic drug of the biguanide classused in type 2 diabetic patients with normal renal function. The mortality rate is high in cases of lactic acidos is developing in metformin intoxication. In the emergency department, metformin intoxication should be considered in the differential diagnosis of patients whouse metformin and have high anion gap metabolic acidosis (lactic acidosis). The most important and effective treatment with early diagnosis is correction of metabolic acidosis with hemodialysis or hemofiltration methods, bicarbonate treatment, adjustment of blood glucose level. Cardiovascular system support therapy significantly reduces morbidity/mortality. In this case report, we present the early diagnosis and successful treatment of a patient with lactic acidosis due to metformin intoxication.
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